Korean J Radiol.  2019 Jun;20(6):894-908. 10.3348/kjr.2018.0540.

Multiparametric Functional Magnetic Resonance Imaging for Evaluating Renal Allograft Injury

Affiliations
  • 1Department of Medical Imaging, Jinling Hospital, Clinical School of Southern Medical University, Nanjing, China.
  • 2Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. kevinzhlj@163.com
  • 3Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
  • 4Medical Imaging Teaching and Research Office, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Abstract

Kidney transplantation is the treatment of choice for patients with end-stage renal disease, as it extends survival and increases quality of life in these patients. However, chronic allograft injury continues to be a major problem, and leads to eventual graft loss. Early detection of allograft injury is essential for guiding appropriate intervention to delay or prevent irreversible damage. Several advanced MRI techniques can offer some important information regarding functional changes such as perfusion, diffusion, structural complexity, as well as oxygenation and fibrosis. This review highlights the potential of multiparametric MRI for noninvasive and comprehensive assessment of renal allograft injury.

Keyword

Multiparametric magnetic resonance imaging; Functional MRI; Kidney transplantation; Allograft fibrosis; Allograft dysfunction
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