Nutr Res Pract.  2018 Oct;12(5):371-377. 10.4162/nrp.2018.12.5.371.

Platycodi radix beverage ameliorates postprandial lipemia response through lipid clearance of triglyceride-rich lipoprotein: A randomized controlled study in healthy subjects with a high-fat load

Affiliations
  • 1Department of Nutritional Science and Food Management, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea. orank@ewha.ac.kr
  • 2Department of Agrofood Resources, Rural Development Administration National Institute of Agricultural Sciences, Jeonbuk 55365, Korea.
  • 3BiofoodCRO. Ltd., Seoul 03721, Korea.

Abstract

BACKGROUND/OBJECTIVES
Elevation of postprandial lipemia characterized by a rise in triglyceride (TG)-rich lipoproteins can increase the risk of atherogenesis. The objective of this study was to investigate postprandial lipemia response to a single dietary fat/sugar load test and monitor beneficial changes induced by the consumption of Platycodi radix (AP) beverage in healthy subjects.
SUBJECTS/METHODS
A total of 52 subjects were randomly assigned to either placebo or AP beverage group with a high-fat shake in a randomized controlled crossover trial. Postprandial blood was collected at 0, 1, 2, 4, and 6 h and analyzed for TG and lipoprotein lipase mass. Inhibition of pancreatic lipase was determined in vitro.
RESULTS
AP inhibited pancreatic lipase activity in vitro (IC₅₀ = 5 mg/mL). Compared to placebo beverage, AP beverage consumption with a high-fat shake induced significant increase of plasma lipoprotein lipase mass (P = 0.0111, β estimate = 4.2948) with significant reduction in very low-density lipoprotein (VLDL) TG concentration (P = 0.038, β estimate = −52.69) at 6 h. Based on significant correlation between high-fat dietary scores MEDFICTS and postprandial TG responses in VLDL (P = 0.0395, r = 0.2127), subgroup analysis revealed that 6 h-postprandial VLDL TG response was significantly decreased by AP consumption in subjects with MEDFICTS ≥ 40 (P = 0.0291, β estimate = −7214).
CONCLUSIONS
AP beverage might have potential to alleviate postprandial lipemia through inhibiting pancreatic lipase activity and elevating lipoprotein lipase mass. Subgroup analysis revealed that subjects with high-fat dietary pattern could be classified as responders to AP beverage among all subjects.

Keyword

Platycodi radix; postprandial lipemia; pancreatic lipase; randomized controlled trial

MeSH Terms

Atherosclerosis
Beverages*
Healthy Volunteers*
Hyperlipidemias*
In Vitro Techniques
Lipase
Lipoprotein Lipase
Lipoproteins*
Plasma
Triglycerides
Lipase
Lipoprotein Lipase
Lipoproteins
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