J Nutr Health.  2019 Apr;52(2):139-148. 10.4163/jnh.2019.52.2.139.

Anti-inflammatory effects of mulberry twig extracts on dextran sulfate sodium-induced colitis mouse model

Affiliations
  • 1Department of Food Science and Nutrition, Daegu Catholic University, Gyeongsan, Gyeongbuk 38430, Korea. kimeunj@cu.ac.kr

Abstract

PURPOSE
Ulcerative colitis is a common inflammatory bowel disease. Prolonged colitis can be a risk factor for the development of colorectal cancer. Mulberry twig (MT, Sangzhi), a dry branch of Morus alba L., which is widely distributed throughout East Asia, has been shown to have anti-inflammatory activities in the cells. However, the effects of MT extracts on colitis in in vivo are limited. Therefore, in this study, we investigated the anti-inflammatory effects of MT extracts in the dextran sulfate sodium (DSS)-induced mouse colitis model.
METHODS
Six week-old, male ICR mice were divided into 3 groups: Control (n = 5), DSS (n = 7), and DSS+MT (n = 7) groups. Mice in the DSS and DSS+MT groups were administrated 3% DSS in drinking water for 5 days to induce colitis. At the same time, water extracts of MT (5 g/kg body weight/day) were orally administered to mice in the DSS+MT groups for 5 days.
RESULTS
The MT extracts significantly reduced the clinical and pathological characteristics of colitis. Disease activity index, mucosal thickness, and colonocyte proliferation were significantly reduced in the DSS+MT group compared with the DSS group. Furthermore, MT administration reduced the levels of plasma TNF-α, IL-6, and the colonic myeloperoxidase activity as well as mRNA expression of TNF-α, IL-6, Cox-2, and iNOS.
CONCLUSION
Taken together, these results suggest that MT water extracts have potent anti-colitis activities in the mouse colitis model.

Keyword

mulberry twig; Morus alba L.; colitis; dextran sulfate sodium; mouse
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