Ann Dermatol.  2019 Jun;31(3):315-319. 10.5021/ad.2019.31.3.315.

Topical Brimonidine as an Effective Adjuvant to Local Anesthetics for Post Treatment Erythema and Pain Reduction

Affiliations
  • 1Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea. momo920@hanmail.net
  • 2Yonsei Star Skin & Laser Clinic, Seoul, Korea.
  • 3Louis Dermatologic Clinic, Guri, Korea.

Abstract

BACKGROUND
There are few pharmacologic options to reduce laser-associated post treatment erythema and to extend topical anesthesia duration. To improve the tolerability of painful laser treatment, dermatologists should encourage development of a novel adjuvant agent to topical lidocaine cream.
OBJECTIVE
To report the efficacy and safety of a combination of topical brimonidine and anesthetic cream as an aid for post treatment erythema and pain.
METHODS
A total of 15 Korean subjects were randomized to receive a split-face application of a mixture of brimonidine and anesthetics on one side and only anesthetics on the other side of the face for anesthesia. After non-ablative fractional full-face skin resurfacing, Clinician's Erythema Assessment, erythema index, and visual analogue scale were assessed at four time points: immediately after resurfacing, 30 minutes after, 60 minutes after, and 1 day after.
RESULTS
A combination of brimonidine and anesthetics significantly lowered post treatment erythema until 60 minutes after the laser procedure. Furthermore, patients reported significantly lower post-procedural pain from the side of their face that received the mixture of anesthetics and brimonidine than they did for the side that only received anesthetics.
CONCLUSION
Topical brimonidine can be used as an effective adjuvant agent to lidocaine-based topical anesthetics.

Keyword

Alpha-2-agonist; Anesthesia; Brimonidine tartrate; Erythema; Pain

MeSH Terms

Anesthesia
Anesthetics
Anesthetics, Local*
Brimonidine Tartrate*
Erythema*
Humans
Lidocaine
Skin
Anesthetics
Anesthetics, Local
Brimonidine Tartrate
Lidocaine
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