Dement Neurocogn Disord.  2019 Mar;18(1):10-18. 10.12779/dnd.2019.18.1.10.

Clinical and Demographic Predictors of Adverse Outcomes in Caregivers of Patients with Dementia

• Lee SM
• Lee Y
• Choi SH
• Lim TS
• Moon SY
• Caregivers of Alzheimer's Disease Research Investigators

• KMID: 2444263
• DOI: http://doi.org/10.12779/dnd.2019.18.1.10

Abstract

BACKGROUND AND PURPOSE
We aimed to elucidate independent predictors of adverse outcomes in caregivers of patients with dementia using readily available clinical and demographic data of patients with dementia and their caregivers.
METHODS
We reviewed patient-caregiver data from the Clinical Research Center for Dementia of South Korea and Caregivers of Alzheimer Disease Research study. The clinical factors of the patients and the demographics of both patients and caregivers were used to predict adverse outcomes for caregivers. Correlation and linear regression analyses were performed.
RESULTS
We enrolled 454 patients and their caregivers for the present study. The general burden for the caregiver was higher amongst female caregivers, patients with further decreased the level of activities of daily living (ADL), patients with more abnormal behavior, or younger patients. The time spent by the caregivers was more in cases of patients with higher Caregiver Administered Neuropsychiatric Inventory scores, younger patients and for patients with decreased level of ADL. Depression amongst caregivers was more prominent in patients with higher Clinical Dementia Rating Sum of Boxes scores. Physical health-related quality of life (HRQoL) was lower in female caregivers, more physically affected patients, and older caregivers. Lastly, mental HRQoL was lower in younger, more physically affected, and in patients with abnormal behaviors.
CONCLUSIONS
Clinical and demographic characteristics of patients and caregivers predict adverse outcomes for caregivers. Therefore, these factors should be considered to provide support to both patients and their caregivers.

Keyword

Dementia; Caregivers; Burden

MeSH Terms

Activities of Daily Living
Alzheimer Disease
Caregivers*
Dementia*
Demography
Depression
Female
Humans
Korea
Linear Models
Quality of Life

Figure

• 

  Fig. 1 Summary diagram of the results of linear regression analysis. K-MMSE: Korean version of the Mini-Mental State Examination, CDR-SB: Clinical Dementia Rating Sum of Boxes, S-IADL: Seoul Instrumental Activities of Daily Living, BADL: Barthel Activity of Daily Living, CGA-NPI: Caregiver Administered Neuropsychiatric Inventory, ZBI: Zarit Burden Interview, CAS-K: Korean version of the Caregiver Activity Survey, BDI: Beck Depression Inventory, HRQoL: health-related quality of life.

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