Clin Nutr Res.  2019 Jan;8(1):55-63. 10.7762/cnr.2019.8.1.55.

Effect of High β-glucan Barley on Postprandial Blood Glucose Levels in Subjects with Normal Glucose Tolerance: Assessment by Meal Tolerance Test and Continuous Glucose Monitoring System

Affiliations
  • 1Department of Diabetes and Endocrinology, Saiseikai Yokohamashi Tobu Hospital, Yokohama 230-0012, Japan. mariko-h@wb3.so-net.ne.jp
  • 2Diabetes, Metabolism and Endocrinology, Toho University, Tokyo 143-8541, Japan.
  • 3Nutrition Support Team, Saiseikai Yokohamashi Tobu Hospital, Yokohama 230-0012, Japan.
  • 4Department of Food Science, Faculty of Home Economics, Otsuma Women's University, Tokyo 102-8357, Japan.

Abstract

The effect of white rice (WR) mixed with high β-glucan-containing barley at 50% on improvement of postprandial blood glucose levels was assessed by meal tolerance test and continuous glucose monitoring (CGM) in 15 healthy subjects with normal glucose tolerance (age 31.6 ± 12.9 years old, 4 males and 11 females). A meal tolerance test (500 kcal) was conducted using 2 types of test meals: a test meal only with WR and a test meal WR mixed 50% barley, and the side dish was the same in both meals. Blood glucose levels of the subjects 180 minutes after ingestion of the test meals were compared. In addition, a CGM device was attached to the subjects for 2 days when the WR or barley as a staple food was provided 3 times a day for consecutive days, and the daily variation of glucose was investigated. The glucose levels 30 minutes after dietary loads and the area under the blood concentration-time curve over 180 minutes were significantly decreased in the barley consumption group. In CGM, 24-hour mean blood glucose and 24-hour standard deviation of blood glucose were also significantly decreased after ingestion of the barley. Postprandial glucose level elevation was suppressed by mixing high-β-glucan barley with WR in subjects with normal glucose tolerance.

Keyword

Diet therapy; Beta glucan; Barley; Postprandial hyperglycemia; Glucose monitoring; Meal tolerance

MeSH Terms

Blood Glucose*
Diet Therapy
Eating
Glucose*
Healthy Volunteers
Hordeum*
Humans
Hyperglycemia
Male
Meals*
Blood Glucose
Glucose

Figure

  • Figure 1 The IAUC of blood glucose over 180 minutes after WR diet or BR diet. IAUC, incremental area under the curve; WR diet, only white rice as staple food; BR diet, white rice mixed with 50% β-glucan rich barley as staple food.

  • Figure 2 Changes in urinary 8-OHdG levels after test meals with WR diet or BR diet. 8-OHdG, 8-hydroxydeoxyguanosine; WR diet, only white rice as staple food; BR diet, white rice mixed with 50% β-glucan rich barley as staple food.


Cited by  1 articles

Effect of High β-glucan Barley on Postprandial Blood Glucose and Insulin Levels in Type 2 Diabetic Patients
Yukie Fuse, Mariko Higa, Naoko Miyashita, Asami Fujitani, Kaoru Yamashita, Takamasa Ichijo, Seiichiro Aoe, Takahisa Hirose
Clin Nutr Res. 2020;9(1):43-51.    doi: 10.7762/cnr.2020.9.1.43.


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