J Menopausal Med.  2019 Apr;25(1):63-68. 10.6118/jmm.2019.25.1.63.

Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms: A Pilot Study

Affiliations
  • 1Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA, USA. takacsp@evms.edu
  • 2Department of Obstetrics and Gynecology, University of Debrecen Faculty of Medicine, Debrecen, Hungary.

Abstract


OBJECTIVES
Although vaginal estrogen is highly effective in alleviating genitourinary symptoms of menopause (GSM), some women are reluctant to use hormonal treatment. Our aim was to evaluate the effect of a zinc-containing vaginal moisturizer gel on GSM.
METHODS
Women with GSM were enrolled. Patients were asked to use the vaginal gel daily for 2 weeks. Vaginal Health Index (VHI) was calculated. Visual analogue scale (VAS) was obtained on vaginal pain, dryness, burning, itching, dyspareunia and dysuria before and 2 weeks after the completion of treatment. Vaginal cytology was obtained. Vulvovaginal symptom questionnaire (VSQ-21) was used to assess subjective symptoms.
RESULTS
Thirty-seven women with GSM participated in the study. The VHI improved significantly (mean ± standard deviation, 13 ± 4 before vs. 17 ± 4 after treatment, P < 0.01). The patient reported VAS combined score was significantly lower after the treatment (18 ± 14 before vs. 7 ± 12 after treatment, P < 0.01). The largest improvement occurred in vaginal dryness. The maturation value did not change significantly. There were no signs of inflammation on vaginal cytology. VSQ-21 combined scores also improved significantly (7.9 ± 5.5 before vs. 2.7 ± 3.6 after the intervention, P < 0.01). Side effects were rare and minor.
CONCLUSIONS
Novel zinc-containing vaginal moisturizer gel significantly improves postmenopausal vulvovaginal symptoms without serious side effects.

Keyword

Zinc; Vagina; Menopause

MeSH Terms

Burns
Dyspareunia
Dysuria
Estrogens
Female
Humans
Inflammation
Menopause
Pilot Projects*
Pruritus
Vagina
Vaginal Creams, Foams, and Jellies
Zinc
Estrogens
Vaginal Creams, Foams, and Jellies
Zinc

Reference

1. Weber MA, Limpens J, Roovers JP. Assessment of vaginal atrophy: a review. Int Urogynecol J. 2015; 26:15–28. PMID: 25047897.
Article
2. Bachmann GA, Nevadunsky NS. Diagnosis and treatment of atrophic vaginitis. Am Fam Physician. 2000; 61:3090–3096. PMID: 10839558.
3. Levine KB, Williams RE, Hartmann KE. Vulvovaginal atrophy is strongly associated with female sexual dysfunction among sexually active postmenopausal women. Menopause. 2008; 15:661–666. PMID: 18698279.
Article
4. Nappi RE, Kokot-Kierepa M. Women's voices in the menopause: results from an international survey on vaginal atrophy. Maturitas. 2010; 67:233–238. PMID: 20828948.
Article
5. Shobeiri F, Jenabi E, Hazavehei SM, Roshanaei G. Quality of life in postmenopausal women in Iran: a population-based study. J Menopausal Med. 2016; 22:31–38. PMID: 27152311.
Article
6. Gandhi J, Chen A, Dagur G, Suh Y, Smith N, Cali B, et al. Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management. Am J Obstet Gynecol. 2016; 215:704–711. PMID: 27472999.
7. Kim HK, Kang SY, Chung YJ, Kim JH, Kim MR. The recent review of the genitourinary syndrome of menopause. J Menopausal Med. 2015; 21:65–71. PMID: 26357643.
Article
8. Management of symptomatic vulvovaginal atrophy: 2013 position statement of The North American Menopause Society. Menopause. 2013; 20:888–902. quiz 903–4. PMID: 23985562.
9. Takacs P, Jaramillo S, Zhang Y, Datar R, Williams A, Olczyk J, et al. The effects of PPARδ agonist and zinc on ovariectomized rats' vagina. Female Pelvic Med Reconstr Surg. 2013; 19:126–131. PMID: 23611928.
Article
10. Takacs P, Zhang Y, Candiotti K, Jaramillo S, Medina CA. Effects of PPAR-delta agonist and zinc on vaginal smooth muscle cells collagen and tropoelastin production. Int Urogynecol J. 2012; 23:1775–1779. PMID: 22576330.
Article
11. Taneja SK, Kaur R. Pathology of ovary, uterus, vagina and gonadotrophs of female mice fed on Zn-deficient diet. Indian J Exp Biol. 1990; 28:1058–1065. PMID: 2283172.
12. Erekson EA, Yip SO, Wedderburn TS, Martin DK, Li FY, Choi JN, et al. The Vulvovaginal Symptoms Questionnaire: a questionnaire for measuring vulvovaginal symptoms in postmenopausal women. Menopause. 2013; 20:973–979. PMID: 23481118.
13. Bachmann G, Cheng RJ, Rovner E. Vulvovaginal complaints. In : Lobo RA, editor. Treatment of the postmenopausal woman. New York: Raven;1994.
14. Kim SH, Park ES, Kim TH. Rejuvenation using platelet-rich plasma and lipofilling for vaginal atrophy and lichen sclerosus. J Menopausal Med. 2017; 23:63–68. PMID: 28523261.
Article
15. Lee YK, Chung HH, Kim JW, Park NH, Song YS, Kang SB. Vaginal pH-balanced gel for the control of atrophic vaginitis among breast cancer survivors: a randomized controlled trial. Obstet Gynecol. 2011; 117:922–927. PMID: 21422866.
16. Bygdeman M, Swahn ML. Replens versus dienoestrol cream in the symptomatic treatment of vaginal atrophy in postmenopausal women. Maturitas. 1996; 23:259–263. PMID: 8794418.
Article
17. Nachtigall LE. Comparative study: replens versus local estrogen in menopausal women. Fertil Steril. 1994; 61:178–180. PMID: 8293835.
Article
18. Dezzutti CS, Brown ER, Moncla B, Russo J, Cost M, Wang L, et al. Is wetter better? An evaluation of over-the-counter personal lubricants for safety and anti-HIV-1 activity. PLoS One. 2012; 7:e48328. PMID: 23144863.
Article
19. Houston DMJ, Robins B, Bugert JJ, Denyer SP, Heard CM. In vitro permeation and biological activity of punicalagin and zinc (II) across skin and mucous membranes prone to Herpes simplex virus infection. Eur J Pharm Sci. 2017; 96:99–106. PMID: 27516148.
Article
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