Dement Neurocogn Disord.  2016 Jun;15(2):37-42. 10.12779/dnd.2016.15.2.37.

The Neuropsychological Characteristics in Early Stage of Alzheimer's Patients with Depression

Affiliations
  • 1Department of Neurology, Seoul Veterans Hospital, Seoul, Korea.
  • 2Department of Neurology, Hyoja Geriatric Hospital, Yongin, Korea. kwakdr@gmail.com

Abstract

BACKGROUND AND PURPOSE
Although depression is a common psychiatric symptom in Alzheimer's disease (AD), there has not been a lot of research on neuropsychological characteristics of this symptom. To determine the characteristic neuropsychological deficit in patients with depression compared to patients without depression, this study compared each neuropsychological test between AD patients with depression and without depression.
METHODS
Psychotropic-naïve (drug-naïve) early stage [Clinical Dementia Rating Scale (CDR)=0.5 or CDR=1] probable AD patients with depression (n=77) and without depression (n=179) were assessed with the Seoul Neuropsychological Screening Battery, which includes measures of memory, intelligence, and executive functioning.
RESULTS
AD patients with depression had lower scores on the digit forward, digit backward, calculation, and Color Word Stroop Test tests compared to AD patients without depression.
CONCLUSION
Our study showed that AD patients with depression have disproportionate cognitive deficit, suggesting frontal (especially in the left dorsolateral), left hemisphere and left parietal dysfunction. Considering the neuropsychological differences between AD patients with depression and without depression, depression may have specific anatomic substrates.

Keyword

Alzheimer's disease; depression; neuropsychological characteristics

MeSH Terms

Alzheimer Disease
Cognition Disorders
Dementia
Depression*
Humans
Intelligence
Mass Screening
Memory
Neuropsychological Tests
Rabeprazole
Seoul
Stroop Test

Cited by  1 articles

Depression and Cognition
Yong Tae Kwak, YoungSoon Yang, Min-Seong Koo
Dement Neurocogn Disord. 2016;15(4):103-109.    doi: 10.12779/dnd.2016.15.4.103.


Reference

1. Mathews A, MacLeod C. Cognitive vulnerability to emotional disorders. Annu Rev Clin Psychol. 2005; 1:167–195.
Article
2. Rose EJ, Ebmeier KP. Pattern of impaired working memory during major depression. J Affect Disord. 2006; 90:149–161.
Article
3. van Reekum R, Simard M, Clarke D, Binns MA, Conn D. Late-life depression as a possible predictor of dementia: cross-sectional and short-term follow-up results. Am J Geriatr Psychiatry. 1999; 7:151–159.
Article
4. Rovner BW, Broadhead J, Spencer M, Carson K, Folstein MF. Depression and Alzheimer's disease. Am J Psychiatry. 1989; 146:350–353.
Article
5. Rubin EH, Kinscherf DA, Grant EA, Storandt M. The influence of major depression on clinical and psychometric assessment of senile dementia of the Alzheimer type. Am J Psychiatry. 1991; 148:1164–1171.
Article
6. Wefel JS, Hoyt BD, Massma PJ. Neuropsychological functioning in depressed versus nondepressed participants with Alzheimer's disease. Clin Neuropsychol. 1999; 13:249–257.
Article
7. Lopez OL, Boller F, Becker JT, Miller M, Reynolds CF 3rd. Alzheimer's disease and depression: neuropsychological impairment and progression of the illness. Am J Psychiatry. 1990; 147:855–860.
Article
8. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984; 34:939–944.
Article
9. Kang Y, Na DL, Hahn S. A validity study on the Korean Mini-Mental State Examination (K-MMSE) in dementia patients. J Korean Neurol Assoc. 1997; 15:300–308.
10. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL. A new clinical scale for the staging of dementia. Br J Psychiatry. 1982; 140:566–572.
Article
11. Mahoney FI, Barthel DW. Functional evaluation: the barthel index. Md State Med J. 1965; 14:61–65.
12. Debruyne H, Van Buggenhout M, Le Bastard N, Aries M, Audenaert K, De Deyn PP, et al. Is the geriatric depression scale a reliable screening tool for depressive symptoms in elderly patients with cognitive impairment? Int J Geriatr Psychiatry. 2009; 24:556–562.
Article
13. Kwak YT, Song SH, Yang Y. The Relationship between Geriatric Depression Scale structure and cognitive-behavioral aspects in patients with Alzheimer's disease. Dement Neurocognitive Disord. 2015; 14:24–30.
Article
14. Bae JN, Cho MJ. Development of the Korean version of the Geriatric Depression Scale and its short form among elderly psychiatric patients. J Psychosom Res. 2004; 57:297–305.
Article
15. Kang Y, Na DL. Seoul Neuropsychological Screening Battery (SNSB). 1st ed. Incheon: Human Brain Research & Consulting Co.;2003.
16. Kaufman AS, McLean JE, Reynolds CR. Analysis of WAIS-R factor patterns by sex and race. J Clin Psychol. 1991; 47:548–557.
Article
17. Hom J, Reitan RM. Neuropsychological correlates of rapidly vs. slowly growing intrinsic cerebral neoplasms. J Clin Neuropsychol. 1984; 6:309–324.
Article
18. Butters N, Delis DC, Lucas JA. Clinical assessment of memory disorders in amnesia and dementia. Annu Rev Psychol. 1995; 46:493–523.
Article
19. Glisky EL, Polster MR, Routhieaux BC. Double dissociation between item and source memory. Neuropsychol. 1995; 9:229–235.
Article
20. Gerton BK, Brown TT, Meyer-Lindenberg A, Kohn P, Holt JL, Olsen RK, et al. Shared and distinct neurophysiological components of the digits forward and backward tasks as revealed by functional neuroimaging. Neuropsychologia. 2004; 42:1781–1787.
Article
21. Phillips LH. Do "frontal tests" measure executive function? Issues of assessment and evidence from fluency tests. In : Rabbit P, editor. Methodology of Frontal and Executive Function. Hove: Psychology Press;1997. p. 191–213.
22. Collette F, Van der Linden M. Brain imaging of the central executive component of working memory. Neurosci Biobehav Rev. 2002; 26:105–125.
Article
23. Bench CJ, Frith CD, Grasby PM, Friston KJ, Paulesu E, Frackowiak RS, et al. Investigations of the functional anatomy of attention using the Stroop test. Neuropsychologia. 1993; 31:907–922.
Article
24. Wise T, Cleare AJ, Herane A, Young AH, Arnone D. Diagnostic and therapeutic utility of neuroimaging in depression: an overview. Neuropsychiatr Dis Treat. 2014; 10:1509–1522.
25. Perret E. The left frontal lobe of man and the suppression of habitual responses in verbal categorical behaviour. Neuropsychologia. 1974; 12:323–330.
Article
26. Stuss DT, Floden D, Alexander MP, Levine B, Katz D. Stroop performance in focal lesion patients: dissociation of processes and frontal lobe lesion location. Neuropsychologia. 2001; 39:771–786.
Article
27. Alexander MP, Stuss DT, Picton T, Shallice T, Gillingham S. Regional frontal injuries cause distinct impairments in cognitive control. Neurology. 2007; 68:1515–1523.
Article
28. Arnone D, McIntosh AM, Ebmeier KP, Munafò MR, Anderson IM. Magnetic resonance imaging studies in unipolar depression: systematic review and meta-regression analyses. Eur Neuropsychopharmacol. 2012; 22:1–16.
Article
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