Allergy Asthma Immunol Res.  2018 Nov;10(6):648-661. 10.4168/aair.2018.10.6.648.

Pollen-Food Allergy Syndrome in Korean Pollinosis Patients: A Nationwide Survey

Affiliations
  • 1Department of Pulmonology, Allergy and Critical Care Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
  • 2Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Chuncheon Sacred Heart Hospital and Nano-Bio Regenerative Medical Institute, Hallym University College of Medicine, Chuncheon, Korea.
  • 3Department of Pediatrics, Pediatric Allergy and Respiratory Center, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea. pedyang@schmc.ac.kr
  • 4Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea.
  • 5Department of Pediatrics Eulji Hospital, Eulji University, Seoul, Korea.
  • 6Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
  • 7Lee & Hong ENT, Sleep and Cosmetic Center, Seongnam, Korea.
  • 8Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
  • 9Department of Pediatrics, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.
  • 10Department of Otorhinolaryngology, Head and Neck Surgery, Dong-A University College of Medicine, Busan, Korea.
  • 11Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
  • 12Department of Pediatrics, Wonkwang University Sanbon Hospital, Wonkwang University College of Medicine, Gunpo, Korea.
  • 13Department of Internal Medicine, Chonnam National University Medical School & Hospital, Gwangju, Korea.
  • 14Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.
  • 15Department of Pediatrics, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.
  • 16Division of Pulmonology and Allergy, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
  • 17Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Korea.
  • 18Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, SoonChunHayng University Hospital, Gumi, Korea.
  • 19Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 20SCH Biomedical Informatics Research Unit, Soonchunhyang University Seoul Hospital, Seoul, Korea.
  • 21Department of Pulmonology and Allergy, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea. mdqueen@hallym.or.kr

Abstract

PURPOSE
Pollen-food allergy syndrome (PFAS) is an immunoglobulin E (IgE)-mediated allergy in pollinosis patients caused by raw fruits and vegetables and is the most common food allergy in adults. However, there has been no nationwide study on PFAS in Korea. In this study, we investigated the prevalence and clinical characteristics of PFAS in Korea.
METHODS
Twenty-two investigators participated in this study, in which patients with allergic rhinoconjunctivitis and/or bronchial asthma with pollen allergy were enrolled. The questionnaires included demographic characteristics, a list of fruits and vegetables, and clinical manifestations of food allergy. Pollen allergy was diagnosed by skin prick test and/or measurement of the serum level of specific IgE.
RESULTS
A total of 648 pollinosis patients were enrolled. The prevalence of PFAS was 41.7% (n = 270). PFAS patients exhibited cutaneous (43.0%), respiratory (20.0%), cardiovascular (3.7%) or neurologic symptoms (4.8%) in addition to oropharyngeal symptoms. Anaphylaxis was noted in 8.9% of the PFAS patients. Seventy types of foods were linked to PFAS; e.g., peach (48.5%), apple (46.7%), kiwi (30.4%), peanut (17.4%), plum (16.3%), chestnut (14.8%), pineapple (13.7%), walnut (14.1%), Korean melon (12.6%), tomato (11.9%), melon (11.5%) and apricot (10.7%). Korean foods such as taro/taro stem (8.9%), ginseong (8.2%), perilla leaf (4.4%), bellflower root (4.4%), crown daisy (3.0%), deodeok (3.3%), kudzu root (3.0%) and lotus root (2.6%) were also linked to PFAS.
CONCLUSIONS
This was the first nationwide study of PFAS in Korea. The prevalence of PFAS was 41.7%, and 8.9% of the PFAS patients had anaphylaxis. These results will provide clinically useful information to physicians.

Keyword

Pollen-food allergy syndrome; pollen; food allergy

MeSH Terms

Adult
Ananas
Anaphylaxis
Arachis
Asthma
Codonopsis
Crowns
Cucurbitaceae
Food Hypersensitivity
Fruit
Humans
Hypersensitivity*
Immunoglobulin E
Immunoglobulins
Juglans
Korea
Lotus
Lycopersicon esculentum
Neurologic Manifestations
Perilla
Pollen
Prevalence
Prunus armeniaca
Prunus domestica
Prunus persica
Pueraria
Research Personnel
Rhinitis, Allergic, Seasonal*
Skin
Vegetables
Immunoglobulin E
Immunoglobulins
Full Text Links
  • AAIR
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error