Clin Psychopharmacol Neurosci.  2019 Feb;17(1):121-124. 10.9758/cpn.2019.17.1.121.

Vitamin D Deficiency/Insufficiency among Inpatients with Depressive Symptoms

  • 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 2Department of Psychiatry, Jeju National University School of Medicine, Jeju, Korea.


Although the association between low vitamin D levels and depressive symptoms has been widely reported, studies investigating the relationship between hypovitaminosis D and depressive symptomatology are scarce.
We retrospectively studied the relationship between vitamin D status and depressive symptoms in 196 patients hospitalized for a major depressive episode.
The baseline 17-item Hamilton Depression Rating Scale total and depression factor (item 1, 2, 3, 7) scores were significantly higher in the vitamin-D-insufficiency/deficiency group than in the vitamin-D-sufficiency group.
It is important to consider measuring the vitamin D levels of patients with severe and core depressive symptoms and providing vitamin D supplementation when necessary.


Vitamin D; Depression; Anhedonia
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