J Korean Neurosurg Soc.  2019 Mar;62(2):183-192. 10.3340/jkns.2017.0314.

Patient-Specific Computational Fluid Dynamics in Ruptured Posterior Communicating Aneurysms Using Measured Non-Newtonian Viscosity : A Preliminary Study

• Lee UY
• Jung J
• Kwak HS
• Lee DH
• Chung GH
• Park JS
• Koh EJ

• KMID: 2441562
• DOI: http://doi.org/10.3340/jkns.2017.0314

Abstract

OBJECTIVE
The objective of this study was to analyze patient-specific blood flow in ruptured aneurysms using obtained non-Newtonian viscosity and to observe associated hemodynamic features and morphological effects.
METHODS
Five patients with acute subarachnoid hemorrhage caused by ruptured posterior communicating artery aneurysms were included in the study. Patients' blood samples were measured immediately after enrollment. Computational fluid dynamics (CFD) was conducted to evaluate viscosity distributions and wall shear stress (WSS) distributions using a patient-specific geometric model and shear-thinning viscosity properties.
RESULTS
Substantial viscosity change was found at the dome of the aneurysms studied when applying non-Newtonian blood viscosity measured at peak-systole and end-diastole. The maximal WSS of the non-Newtonian model on an aneurysm at peaksystole was approximately 16% lower compared to Newtonian fluid, and most of the hemodynamic features of Newtonian flow at the aneurysms were higher, except for minimal WSS value. However, the differences between the Newtonian and non-Newtonian flow were not statistically significant. Rupture point of an aneurysm showed low WSS regardless of Newtonian or non-Newtonian CFD analyses.
CONCLUSION
By using measured non-Newtonian viscosity and geometry on patient-specific CFD analysis, morphologic differences in hemodynamic features, such as changes in whole blood viscosity and WSS, were observed. Therefore, measured non-Newtonian viscosity might be possibly useful to obtain patient-specific hemodynamic and morphologic result.

Keyword

Aneurysm; Viscosity; Wall shear stress; Computational fluid dynamics; Non-Newtonian; Newtonian

MeSH Terms

Aneurysm*
Aneurysm, Ruptured
Blood Viscosity
Hemodynamics
Humans
Hydrodynamics*
Intracranial Aneurysm
Rupture
Subarachnoid Hemorrhage
Viscosity*

Figure

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  Fig. 1. A-E : Patient-specific geometric models of ruptured aneurysms.

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  Fig. 2. Clinically measured blood viscosity profiles.

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  Fig. 3. Whole blood viscosity (WBV) distributions of aneurysms. Whole blood viscosity with Newtonian viscosity at both peak-systole and enddiastole is shown in Newtonian column. Non-Newtonian WBV at peaksystole and WBV using non-Newtonian rheology model at end-diastole are shown according to each aneurysm model. PS : peak-systole, ED :end-diastole.

• 

  Fig. 4. Comparison of the simulation results between Newtonian and nonNewtonian wall shear stress during cardiac cycle at rupture point of aneur ysms. Dif ferent scale bar is applied to each model. The aneurysm rupture point is marked with a red box, and the enlarged view of the ruptured region is also included. PS : peak-systole, ED : end-diastole.

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  Fig. 5. A-E : Normalized mean wall sheer stress (WSS) versus the time. Volume average of Newtonian and non-Newtonian WSS at rupture point of aneurysms. Newtonian was underestimated in most aneurysm results except for aneurysm B and E. See the text for a detailed description.

Reference

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