Korean J Intern Med.  2019 Mar;34(2):335-343. 10.3904/kjim.2017.287.

Evaluation of high resolution computed tomography findings of cystic fibrosis

  • 1Department of Pediatric Allergy and Immunology, Cukurova University School of Medicine, Adana, Turkey. ssashuseyinoglu@yahoo.com.tr
  • 2Department of Radiology, Cukurova University School of Medicine, Adana, Turkey.


Morphological changes due to lung disease in patients with cystic fibrosis (CF) were evaluated using high resolution computed tomography (HRCT), and the HRCT scores obtained using the Bhalla scoring system were correlated with those obtained using clinical and laboratory indicators.
Medical records of 28 children with CF who underwent chest CT in Department of Pediatric Allergy and Immunology, Cukurova University Balcali Hospital between March 2011 and January 2016 were retrospectively reviewed. Demographic data and physical examination, respiratory cultures, pulmonary function tests, and chest HRCT findings were evaluated. Patients were divided into the following two groups according to their forced expiratory volume in the first second (FEV₁) values: normal FEV₁ (≥ 80% of predicted values) and low FEV₁ ( < 80% of predicted values). Deep throat or sputum cultures were evaluated for the presence of Pseudomonas aeruginosa (PsA) and other bacteria. HRCT scans were scored using the Bhalla scoring system.
No significant correlation was found between the Bhalla scores and sex, age group, or height percentiles. Significant relationships were found between the Bhalla score and weight (p = 0.036) and body mass index (BMI) (p = 0.032) percentiles below the third percentile, bacterial growth in the sputum/deep throat cultures (p = 0.009), and presence of PsA (p = 0.004). Moreover, a significant correlation was found between the Bhalla score and FEV₁ (r = −0.315, p = 0.0272), forced vital capacity (FVC; r = −0.381, p = 0.0178), forced expiratory flow between 25% and 75% of FVC (r = −0.229, p = 0.0431), and BMI (r = −3.368, p = 0.050).
Chest HRCT is an important diagnostic tool for the pulmonary evaluation of children with CF.


Cystic fibrosis; Child; Computed tomography; Pulmonary evaluation

MeSH Terms

Allergy and Immunology
Body Mass Index
Cystic Fibrosis*
Forced Expiratory Volume
Lung Diseases
Medical Records
Physical Examination
Pseudomonas aeruginosa
Respiratory Function Tests
Retrospective Studies
Tomography, X-Ray Computed
Vital Capacity
Full Text Links
  • KJIM
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2023 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr