J Korean Med Sci.  2019 Jan;34(3):e23. 10.3346/jkms.2019.34.e23.

Mixed Infection with Plasmodium falciparum and Plasmodium ovale in a Returned Traveller: the First Case in Korea

Affiliations
  • 1Department of Internal Medicine, National Medical Center, Seoul, Korea. simply.gayeon@gmail.com
  • 2Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.
  • 3Department of Laboratory Medicine, National Medical Center, Seoul, Korea.
  • 4Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea.
  • 5Green Cross Laboratories, Yongin, Korea.

Abstract

Mixed-species malaria infections are often unrecognized or underestimated. We hereby report the first described case of mixed infection with Plasmodium falciparum and Plasmodium ovale malaria in a returned traveller in Korea. In August 2016, a 25-year-old returned traveller from Cameroon and Democratic Republic of Congo presented with fever. He was diagnosed as P. falciparum malaria and successfully treated with artesunate. And 5 weeks after the completion of treatment, he presented with fever and diagnosed as P. ovale infection. P. ovale infection is a rare cause of malaria and often shows delayed presentation due to its dormant liver stage as hypnozoites. At re-presentation, the immunochromatographic test and microscopic examinations of our patient did not reveal P. ovale, which was only detected via polymerase chain reaction (PCR) assay. This case highlights the importance of considering malaria infection even in persons who have previously received malaria treatment. It also shows the usefulness of PCR testing for diagnosing P. ovale infections, which often present with a low level of parasitaemia.

Keyword

Mixed Infection; Plasmodium falciparum; Plasmodium ovale

MeSH Terms

Adult
Cameroon
Coinfection*
Congo
Fever
Humans
Korea*
Liver
Malaria
Plasmodium falciparum*
Plasmodium ovale*
Plasmodium*
Polymerase Chain Reaction
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