Korean J Helicobacter Up Gastrointest Res.  2018 Sep;18(3):180-185. 10.7704/kjhugr.2018.18.3.180.

Efficacy of Ecabet Sodium for Helicobacter pylori Eradication with Sequential Therapy

Affiliations
  • 1Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ji110@hanmail.net

Abstract

BACKGROUND/AIMS
We aimed to compare the outcomes of Helicobacter pylori eradication in patients receiving sequential therapy (ST) depending on the use of ecabet sodium (ES).
MATERIALS AND METHODS
Between January to December 2015, 176 patients randomly received either ST alone (n=72) or 10-day ES therapy combined with ST (n=104). After applying the exclusion criteria, 56 patients were finally assigned to the ST-only group and 84 to the ST with ES group. We retrospectively reviewed and analyzed the H. pylori eradication rate and adverse events between the two groups.
RESULTS
Among the 140 patients, 121 (86.4%) achieved successful H. pylori eradication and 24 (17.1%) had adverse events. Eradication was achieved in 50 patients (89.3%) in the ST-only group and in 71 patients (84.5%) in the ST with ES group (P=0.420). No significant difference in the incidence of adverse events was found between the ST-only and ST with ES groups (12.5% vs. 20.2%, respectively; P=0.234). However, the ST with ES group tended to have a higher prevalence of nausea or vomiting than the ST-only group (11.9% vs. 1.8%; P=0.050).
CONCLUSIONS
ST showed a good H. pylori eradication rate without deteriorating the adverse events regardless of adding ES.

Keyword

Ecabet sodium; Helicobacter pylori; Sequential therapy
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