Korean J Helicobacter Up Gastrointest Res.  2018 Sep;18(3):150-156. 10.7704/kjhugr.2018.18.3.150.

Liquid Biopsy: Current Status and Future Perspective in Gastric Cancer and Helicobacter Infection

• Kang EA
• Han YM
• Park JM
• Yoo IK
• Hong SP
• Hahm KB

• KMID: 2439823
• DOI: http://doi.org/10.7704/kjhugr.2018.18.3.150

Abstract

Precision medicine stands for 4Ps - precise, preventive, participatory, and personal; in which "precision" is important because the current modern medicine starts from "trial and error," and "one does not fit all". Current targeted therapies for cancer have changed treatment approaches and led the precision medicine; however, clinical use of liquid biopsy, using blood or other liquid specimens to characterize circulating tumor cells (CTC) or tumor genes instead of biopsies of tumor tissues, still awaits availability of more information regarding non-invasive cancer detection and characterization, prediction of treatment response, monitoring the disease course and relapse possibilities, identification of mechanisms of drug resistance, and newer pathogenesis. In this review, we will introduce the basic concept of CTC, circulating cell free DNA, and exosomes and their possible application for gastric cancer relevant with Helicobacter pylori infection.

Keyword

Cell free DNA; Circulating tumor cell; Exosome; Gastric cancer; Liquid biopsy

MeSH Terms

Biopsy*
DNA
Drug Resistance
Exosomes
Helicobacter Infections*
Helicobacter pylori
Helicobacter*
History, Modern 1601-
Humans
Neoplastic Cells, Circulating
Precision Medicine
Recurrence
Stomach Neoplasms*
DNA