Biomed Eng Lett.  2018 May;8(2):215-221. 10.1007/s13534-018-0059-2.

Naphthalocyanines as contrast agents for photoacoustic and multimodal imaging

Affiliations
  • 1Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA. jflovell@buffalo.edu

Abstract

Naphthalocyanines (Ncs) are a family of aromatic small molecule with large near infrared extinction coefficients, making them appealing contrast agent candidates for photoacoustic imaging (PAI). Depending on the substitutions on the Nc periphery or metal center, different spectrally-resolved absorption peak wavelengths are possible, which can enable photoacoustic contrast multiplexing. Owing to their generally poor aqueous solubility, approaches have been developed to modify Ncs or formulate them as biocompatible contrast agents for PAI. Due to their inherent capacity for metal ion chelation, Ncs hold potential for complementary multimodal contrast imaging techniques such as ⁶⁴Cu positron emission tomography. In this research perspective, we highlight some recent reports involving the use of Ncs in PAI.

Keyword

Photoacoustic; Naphthalocyanines; Multimodal imaging; Contrast agents

MeSH Terms

Absorption
Contrast Media*
Humans
Multimodal Imaging*
Positron-Emission Tomography
Solubility
Contrast Media
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