Ann Dermatol.  2019 Apr;31(2):146-153. 10.5021/ad.2019.31.2.146.

Serotonin Expression in Lichen Planus Lesions and Its Relationship with Depression/Anxiety

Affiliations
  • 1Department of Dermatology, Medical Park Ankara Hospital, Ankara, Turkey. isilkurmus@gmail.com
  • 2Department of Dermatology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
  • 3Department of Pathology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
  • 4Department of Psychiatry, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.

Abstract

BACKGROUND
Psychological factors such as stress, depression, and anxiety have been documented to contribute to the development of lesions in lichen planus (LP).
OBJECTIVE
To evaluate the relationship between serotonin expression in LP lesions and depression/anxiety.
METHODS
Forty patients (22 females, 18 males) with LP and 20 healthy control subjects were included in this study. The severity of LP was assessed with the palmar method (using the measurement of affected body surface area [BSA]). The depression and anxiety scores were measured with Beck's depression inventory (BDI) and Beck's anxiety inventory (BAI). The expression of serotonin was determined via immunohistochemistry in LP lesions and in the control group skin using a monoclonal antibody to serotonin.
RESULTS
The skin biopsies of the LP patients had significantly higher levels of serotonin than those of the control subjects (p < 0.001). In the LP patients, and there was a positive correlation between serotonin expression and LP severity (p=0.022). Based on the results from the BDI and BAI, there was a significant relationship between the severity of depression/anxiety and intensity of serotonin expression (p < 0.001).
CONCLUSION
Data from this study suggest that serotonin may have a possible role in the pathogenesis of LP. Further, the relationship between serotonin expression in acute cutaneous lesions and the depression/anxiety scores indicates that serotonin may be a mediator for the association of LP and depression/anxiety simultaneously. There is a need for more specific studies showing the expression of serotonin in the lichen planus to demonstrate the cause or effect.

Keyword

Anxiety; Depression; Lichen planus; Serotonin

MeSH Terms

Anxiety
Biopsy
Body Surface Area
Depression
Female
Humans
Immunohistochemistry
Lichen Planus*
Lichens*
Methods
Psychology
Serotonin*
Skin
Serotonin

Figure

  • Fig. 1 (A) BDI values, (B) BAI values. BDI: Beck's depression inventory, BAI: Beck's anxiety inventory, LP: lichen planus.

  • Fig. 2 Serotonin expression in the eccrine glands of lichen planus lesions (serotonin mouse monoclonal antibody, 10×20). (A) Grade 0, no staining (−); (B) Grade 1, mild staining (+); (C) Grade 2, moderate staining (++); (D) Grade 3, strong staining (+++).

  • Fig. 3 Immunohistochemical staining of lichen planus lesions for serotonin. (A) Grade 2, moderate staining (++). (B) Grade 3, strong staining (+++).


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