Epidemiol Health.  2018;40:e2018049. 10.4178/epih.e2018049.

Association of appendicular skeletal muscle mass with carotid intima-media thickness according to body mass index in Korean adults

Affiliations
  • 1Department of Public Health, Yonsei University Graduate School, Seoul, Korea.
  • 2Cardiovascular and Metabolic Disease Etiology Research Center, Yonsei University College of Medicine, Seoul, Korea. hckim@yuhs.ac
  • 3Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.

Abstract


OBJECTIVES
The combined effects of obesity and appendicular skeletal muscle (ASM) on atherosclerosis, especially in middle-aged populations, remain poorly understood. This cross-sectional study investigated the effects of ASM on carotid intima-media thickness (IMT) according to body mass index (BMI) in middle-aged Korean adults.
METHODS
Herein, 595 men and 1,274 women aged 30-64 years completed questionnaires and underwent health examinations as part of the Cardiovascular and Metabolic Disease Etiology Research Center cohort. ASM was measured via bioelectrical impedance analysis and adjusted for weight (ASM/Wt). IMT was assessed using B-mode ultrasonography; highest quartile of IMT was defined as gender-specific top quartile of the IMT values. Higher BMIs was defined as a BMI over 25.0 kg/m2.
RESULTS
Compared to the highest ASM/Wt quartile, the lowest ASM/Wt quartile was significantly associated with highest quartile of IMT in men with lower BMIs (adjusted odds ratio [aOR], 2.78; 95% confidence interval [CI], 1.09 to 7.13), but not in those with higher BMIs (aOR, 0.59; 95% CI, 0.24 to 1.91). In women, there was no significant association of low skeletal muscle mass with highest quartile of IMT, regardless of BMI.
CONCLUSION
Low appendicular skeletal muscle mass is associated with carotid arterial wall thickening in men with lower BMIs, but not in men with higher BMIs. Our findings suggest that the risk of atherosclerosis may be low in middle-aged Korean men with appropriate body weight and skeletal muscle mass maintenance.

Keyword

Sarcopenia; Muscles; Skeletal; Body mass index; Body composition; Atherosclerosis

MeSH Terms

Adult*
Atherosclerosis
Body Composition
Body Mass Index*
Body Weight
Carotid Intima-Media Thickness*
Cohort Studies
Cross-Sectional Studies
Electric Impedance
Female
Humans
Male
Metabolic Diseases
Muscle, Skeletal*
Muscles
Obesity
Odds Ratio
Sarcopenia
Ultrasonography
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