Restor Dent Endod.  2019 Feb;44(1):e7. 10.5395/rde.2019.44.e7.

Endodontic biofilms: contemporary and future treatment options

Affiliations
  • 1Department of Conservative Dentistry, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea. kum6139@snu.ac.kr
  • 2Division of Restorative Dentistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada.
  • 3Department of Conservative Dentistry, School of Dentistry, Kyung Hee University, Seoul, Korea.
  • 4Department of Oral Microbiology and Immunology, Dental Research Institute and BK21 Plus Program, School of Dentistry, Seoul National University, Seoul, Korea.

Abstract

Apical periodontitis is a biofilm-mediated infection. The biofilm protects bacteria from host defenses and increase their resistance to intracanal disinfecting protocols. Understanding the virulence of these endodontic microbiota within biofilm is essential for the development of novel therapeutic procedures for intracanal disinfection. Both the disruption of biofilms and the killing of their bacteria are necessary to effectively treat apical periodontitis. Accordingly, a review of endodontic biofilm types, antimicrobial resistance mechanisms, and current and future therapeutic procedures for endodontic biofilm is provided.

Keyword

Antimicrobial resistance; Endodontic biofilm; Intracanal disinfection; Lactobacillus; Lipoteichoic acid

MeSH Terms

Bacteria
Biofilms*
Disinfection
Homicide
Lactobacillus
Microbiota
Periapical Periodontitis
Virulence
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