Psychiatry Investig.  2019 Jan;16(1):71-79. 10.30773/pi.2018.10.26.

Multidimensional Comparison of Cancer-Related Fatigue and Chronic Fatigue Syndrome: The Role of Psychophysiological Markers

Affiliations
  • 1Department of Psychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. iyoon@snu.ac.kr
  • 2Department of Psychiatry, Konkuk University Medical Center, Seoul, Republic of Korea.
  • 3Department of Psychiatry, Dong-A University Hospital, Busan, Republic of Korea.
  • 4Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.

Abstract


OBJECTIVE
The present study compared cancer-related fatigue (CRF) and chronic fatigue syndrome (CFS) using multidimensional measurements with the aim of better understanding characteristics and exploring markers of two similar fatigue syndromes.
METHODS
Twenty-five patients with CRF and twenty patients with CFS completed questionnaires, including the Fatigue Severity Scale (FSS), Hospital Anxiety Depression Scale (HADS), Perceived Stress Scale (PSS), and Pittsburgh Sleep Quality Index (PSQI). Additionally, levels of high sensitivity C-reactive protein (hs-CRP), heart rate variability (HRV), and electroencephalography (EEG) were obtained. Neurocognitive functioning was also evaluated.
RESULTS
Both groups showed comparable levels of psychological variables, including fatigue. Compared to CFS subjects, CRF patients had significantly higher hs-CRP levels and a reduced HRV-index. The within-group analyses revealed that the FSS score of the CRF group was significantly related to scores on the HADS-anxiety, HADS-depression, and PSQI scales. In the CFS group, FSS scores were significantly associated with scores on the PSS and the absolute delta, theta, and alpha powers in frontal EEG.
CONCLUSION
Findings indicate that different pathophysiological mechanisms underlie CFS and CRF. Inflammatory marker and HRV may be potential biomarkers for distinguishing two fatigue syndromes and frontal EEG parameters may be quantitative biomarkers for CFS.

Keyword

Fatigue; Cancer; Biomarkers; Electrocardiography; Electroencephalography

MeSH Terms

Anxiety
Biomarkers
C-Reactive Protein
Depression
Electrocardiography
Electroencephalography
Fatigue Syndrome, Chronic*
Fatigue*
Heart Rate
Humans
Weights and Measures
Biomarkers
C-Reactive Protein
Full Text Links
  • PI
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error