Korean J Psychosom Med.  2018 Jun;26(1):59-67. 10.22722/KJPM.2018.26.1.59.

Factors Influencing on the Cognitive Function in Type 2 Diabetics

Affiliations
  • 1Department of Psychiatry, Kosin University College of Medicine, Busan, Korea. cheonjs@kosin.ac.kr
  • 2Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
  • 3Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea.

Abstract


OBJECTIVES
The aims of this study were to know the frequency and the nature of cognitive dysfunction in type 2 diabetics, and to reveal influencing variables on it.
METHODS
From eighty type 2 diabetics (42 males and 38 females), demographic and clinical data were obtained by structured interviews. Cognitive functions were measured using the MMSE-K (Korean Version of the Mini-Mental State Examination) and the Korean Version of the Montreal Cognitive Assessment (MoCA-K) tests. Severity of depression was evaluated by the Korean Version of the Hamilton Depression Rating Scale (K-HDRS).
RESULTS
1) Among eighty type 2 diabetics, 13.75% were below 24 on the MMSE-K, while 38.8% were below 22 on the MoCA-K. 2) The total scores and subtest scores of the MoCA-K including visuospatial/executive, attention, language, delayed recall and orientation were significantly lower in type 2 diabetics with cognitive dysfunction (N=31) than those without cognitive dysfunction (N=49) (p < 0.001, respectively). 3) There were significant difference between type 2 diabetics with and those without cognitive dysfunction in age, education, economic status, body mass index, duration of diabetes, total scores of the K-HDRS, the MMSE-K and the MoCA-K (p < 0.05, respectively). 4) The total scores of the MoCA-K had significant correlation with age, education, body mass index, family history of diabetes, duration of diabetes, total scores of the K-HDRS (p < 0.05, respectively). 5) The risks of cognitive dysfunction in type 2 diabetics were significantly influenced by sex, education, fasting plasma glucose and depression.
CONCLUSIONS
The cognitive dysfunction in type 2 diabetics seemed to be related to multiple factors. Therefore, more comprehensive biopsychosocial approaches needed for diagnosis and management of type 2 diabetes.

Keyword

Type 2 diabetes; Cognitive dysfunction; Sex; Education; Depression

MeSH Terms

Blood Glucose
Body Mass Index
Cognition*
Depression
Diagnosis
Education
Fasting
Humans
Male
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