Keimyung Med J.  2018 Jun;37(1):17-21. 10.0000/kmj.2018.37.1.17.

Prognostic Value of TZAP Expression in Various Cancers: TCGA Data Analysis

Affiliations
  • 1Department of Anatomy, Keimyung University School of Medicine, Daegu, Korea. anato82@dsmc.or.kr

Abstract

The zinc finger protein ZBTB48 is a telomere-associated factor and renamed it as telomeric zinc finger-associated protein (TZAP). It binds preferentially to long telomeres competing with TRF1 and TRF2. However, its expression in cancers has not been performed. In the present study, we analyzed the prognosis of TZAP expression in 22 kinds of cancers by using TCGA data analysis. TZAP expression had a prognostic value in cervical, colon, and pancreatic cancers. When sorting the patients differently, it got the significance in bladder, breast, kidney, brain, and lung cancers. TZAP expression was associated with better prognosis in bladder, breast, cervical, lung, and pancreatic cancers. However, it showed poorer survival results in colon, kidney, and brain cancers. This result suggested that TZAP expression appears to be a possible prognosis marker in various cancers.

Keyword

TCGA; Telomere; TZAP; ZBTB48

MeSH Terms

Brain
Brain Neoplasms
Breast
Colon
Humans
Kidney
Lung
Lung Neoplasms
Pancreatic Neoplasms
Prognosis
Statistics as Topic*
Telomere
Urinary Bladder
Zinc
Zinc Fingers
Zinc
Full Text Links
  • KMJ
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr