Korean J Blood Transfus.  2018 Aug;29(2):182-187. 10.17945/kjbt.2018.29.2.182.

-D-/-D- Phenotype Frequency among Korean Donors

  • 1Korean Red Cross Central Blood Laboratory Center, Seoul, Korea. mklee@redcross.or.kr
  • 2Korean Red Cross Blood Services, Wonju, Korea.


To improve Rh-related antigen negative blood supply effectively, the Korean Red Cross (KRC) blood centers have performed Rh phenotype screening tests of C, c, E and e antigens for all donors since April, 2013. Especially for rare "˜-D-/-D-' blood supply and donor recruitment, we have implemented Rh phenotype confirmation test for all C, c, E and e antigen negative donors. In this study, we report the test results of 7 donors with "˜-D-/-D-' phenotype.
All three KRC Blood Laboratory Centers performed Rh phenotype screening tests using the automatic machine, PK7300 (Beckman Coulter, Japan), for all 876,920 donors from January 1, 2018 to April 30, 2018. We then performed the Rh phenotype confirmation test using the tube method manually, at room temperature, 37℃ and antihuman globulin phase.
Among 876,920 donors, 14 were Rh antigen C, c, E, e negative as results of Rh phenotype screening test. The results of Rh phenotype confirmation test of these 14 donors showed that 7 donors were Rh antigen C, c, E, e negative. The ratio of -D-/-D- phenotype for all donors was 0.000798%.
Our data suggests that -D-/-D- phenotype is one of the rare blood groups among Koreans. Although "˜-D-/-D-' phenotype was confirmed by serologic tests, it is necessary to re-confirm it by molecular genetic techniques.


-D-/-D-; Rh phenotype; rare blood
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