J Neurocrit Care.  2018 Dec;11(2):134-136. 10.18700/jnc.180073.

A Variant Guillain-Barré Syndrome with Anti-Ganglioside Complex Antibody

Affiliations
  • 1Department of Neurology, Kosin University College of Medicine, Busan, Korea. caccu@naver.com
  • 2Department of Neurology, Dong-A University College of Medicine, Busan, Korea.
  • 3Peripheral Neuropathy Research Center, Dong-A University College of Medicine, Busan, Korea.

Abstract

BACKGROUND
Recently, anti-ganglioside complex (GSC) antibodies were discovered among the various subtypes of Guillain-Barré syndrome. GSC is the novel glycoepitopes formed by two individual ganglioside molecules.
CASE REPORT
We present a 36-year-old man with overlap Miller Fisher syndrome and acute bulbar palsy who had anti-GSC antibody that provided diagnostic robustness.
CONCLUSION
Anti-GSC testing could be considered important in patients who show atypical manifestation with negative antibody reaction against each constituent ganglioside.

Keyword

Guillain-Barre syndrome; Miller Fisher syndrome; Antibodies; Gangliosides

MeSH Terms

Adult
Antibodies
Bulbar Palsy, Progressive
Gangliosides
Guillain-Barre Syndrome*
Humans
Miller Fisher Syndrome
Antibodies
Gangliosides

Cited by  1 articles

Overlap syndrome of Miller-Fisher syndrome/Pharyngeal-Cervical-Brachial variant-Guillain Barre Syndrome with anti-ganglioside complex antibodies
Suk-yoon Lee, Seong-il Oh, So-Young Huh, Kyong Jin Shin, Jong Kuk Kim, Byeol-A Yoon
Ann Clin Neurophysiol. 2020;22(2):112-116.    doi: 10.14253/acn.2020.22.2.112.


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