Korean J Biol Psychiatry.  2018 Aug;25(3):79-87. 10.0000/kjbp.2018.25.3.79.

Effect of Stress and Serotonin-Transporter-Linked Polymorphic Region Variants on Internet Gaming Disorder in Korean Adults

Affiliations
  • 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea. kdj922@catholic.ac.kr
  • 2Addiction Laboratory, Department of Psychiatry, College of Medicine, The Catholic of University of Korea, Seoul, Korea.
  • 3Department of Psychology, Korea University, Seoul, Korea.
  • 4Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.
  • 5Truemind Mental Health Clinic, Seoul, Korea.

Abstract


OBJECTIVES
Internet gaming disorder (IGD) is known to be related to stress and the serotonin-transporter-linked polymorphic region (5-HTTLPR) that is known to be associated with stress and has been studied to affect various psychiatric illness outbreaks. We tried to examine the relationship between stress, 5-HTTLPR and IGD.
METHODS
A total of 59 participants with IGD, diagnosed according to the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria and 67 normal controls (NC) were enrolled. The IGD group and the NC were compared using chisquare test and independent sample t-test, and logistic regression analysis was used to examine the relationship between stress, the 5-HTTLPR, and IGD.
RESULTS
The mean scores for anxiety, impulsivity and stress were significantly higher in the IGD group than in the NC. In addition, there was a significant association between stress and IGD [odds ratio (OR) = 1.172, 95% confidence interval (CI) = 1.008-1.362].
CONCLUSIONS
This study showed that stress would affect IGD. Therefore, the evaluation and management of stress should be included in the diagnosis and treatment of IGD.

Keyword

Internet gaming disorder; Stress; Serotonin-transporter-linked polymorphic region

MeSH Terms

Adult*
Anxiety
Diagnosis
Diagnostic and Statistical Manual of Mental Disorders
Disease Outbreaks
Humans
Immunoglobulin D
Impulsive Behavior
Internet*
Logistic Models
Immunoglobulin D
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