Korean J Biol Psychiatry.  2018 Feb;25(1):1-8. 10.0000/kjbp.2018.25.1.1.

The Roles of Frontal Cortex in Primary Insomnia : Findings from Functional Magnetic Resonance Imaging Studies

  • 1Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, Korea. jungyoon.kimm@ewha.ac.kr
  • 2Ewha Brain Institute, Ewha Womans University, Seoul, Korea. hanbyul.h.cho@gmail.com


Insomnia is a common sleep-related symptom which occurs in many populations, however, the neural mechanism underlying insomnia is not yet known. The hyperarousal model explains the neural mechanism of insomnia to some extent, and the frontal cortex dysfunction has been known to be related to primary insomnia. In this review, we discuss studies that applied resting state and/or task-related functional magnetic resonance imaging to demonstrate the deficits/dysfunctions of functional activation and network in primary insomnia. Empirical evidence of the hyperarousal model and proposed relation between the frontal cortex and other brain regions in primary insomnia are examined. Reviewing these studies could provide critical insights regarding the pathophysiology, brain network and cerebral activation in insomnia and the development of novel methodologies for the diagnosis and treatment of insomnia.


Sleep; Primary insomnia; fMRI; Frontal cortex; Functional connectivity
Full Text Links
  • KJBP
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2021 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr