Psychiatry Investig.  2018 Dec;15(12):1174-1180. 10.30773/pi.2018.11.01.

Gray Matter Volume Reductions Were Associated with TPH1 Polymorphisms in Depressive Disorder Patients with Suicidal Attempts

  • 1Department of Psychiatry, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
  • 2Department of Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
  • 3Department of Radiology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
  • 4Department of Pharmacology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
  • 5Department of Biomedical Laboratory Science, Catholic Kwandong University, Gangneung, Republic of Korea.


Structural changes of brain areas have been reported in depressive disorder and suicidal behavior (SB), in which TPH1 also has been known as a promising candidate gene. We investigated gray matter volume (GMV) differences, TPH1 rs1800532 and rs1799913 polymorphisms previously found to be associated with depressive disorder and SB, and the relationship between the two markers.
Thirteen depressive disorder patients with suicidal attempts (SA) and twenty healthy controls were included. We examined GMV differences using a voxel-based morphometry and regions of interest analysis. Direct sequencing was used for genotyping.
The patients showed significant GMV reduction in left cerebral region including middle frontal gyrus, inferior frontal gyrus, and anterior cingulate cortex; in right middle temporal gyrus; in left cerebellar tonsil; and in right cerebral region including precentral gyrus and postcentral gyrus (corrected p < 0.005). The right precentral and postcentral gyri GMV values of AA and CA genotypes patients were significantly decreased compared to those of CC genotype subjects (corrected p=0.040).
These findings show the possibility that both GMV reductions and TPH1 rs1800532/rs1799913 A allele may be involved in the pathogenesis of depressive disorder patients with SA.


Depressive disorder; Suicidal attempt; Gray matter volume; TPH1 gene
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