Ann Lab Med.  2018 Sep;38(5):492-494. 10.3343/alm.2018.38.5.492.

PCM1-JAK2 Fusion in a Patient With Acute Myeloid Leukemia

Affiliations
  • 1Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. microkim@catholic.ac.kr
  • 2Catholic Genetic Laboratory Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul,Korea.
  • 3Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

No abstract available.


MeSH Terms

Humans
Leukemia, Myeloid, Acute*

Figure

  • Fig. 1 Bone marrow (BM) findings. (A) Myeloblasts showing less cytoplasm and distinct prominent nucleoli at initial diagnosis (April 2011) (Wright stain, ×400); (B) CD34-positive myeloblasts in the BM biopsy (November 2011) (immunohistochemistry stain, ×400); (C) increased immature cells in touch preparation (March 2012) (Wright stain, ×400); (D–F) serial BM biopsies showing fibrosis progression (April 2011, November 2011, and March 2012, respectively) (hematoxylin & eosin stain ×200).

  • Fig. 2 The t(8;9)(p21;p24) translocations and PCM1-JAK2 fusion gene. (A) Karyogram of BM showing 46,XX,t(8;9)(p21;p24), (B) Sequence of the chimeric PCM1-JAK2 gene showing in-frame fusion between exon 30 of PCM1 and exon 9 of JAK2.


Reference

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