Yeungnam Univ J Med.  2019 Jan;36(1):54-58. 10.12701/yujm.2019.00017.

Estrogen-secreting adrenocortical carcinoma

• Jeong Y
• Cho SC
• Cho HJ
• Song JS
• Kong JS
• Park JW
• Ku YH

• KMID: 2434100
• DOI: http://doi.org/10.12701/yujm.2019.00017

Abstract

Adrenocortical carcinoma is a rare type of endocrine malignancy with an annual incidence of approximately 1-2 cases per million. The majority of these tumors secrete cortisol, and a few secrete aldosterone or androgen. Estrogen-secreting adrenocortical carcinomas are extremely rare, irrespective of the secretion status of other adrenocortical hormones. Here, we report the case of a 53-year-old man with a cortisol and estrogen-secreting adrenocortical carcinoma. The patient presented with gynecomastia and abdominal discomfort. Radiological assessment revealed a tumor measuring 21×15.3×12 cm localized to the retroperitoneum. A hormonal evaluation revealed increased levels of estradiol, dehydroepiandrosterone sulfate, and cortisol. The patient underwent a right adrenalectomy, and the pathological examination revealed an adrenocortical carcinoma with a Weiss' score of 6. After surgery, he was treated with adjuvant radiotherapy. Twenty-one months after treatment, the patient remains alive with no evidence of recurrence.

Keyword

Adrenal gland neoplasm; Adrenocortical carcinoma, Estrogen; Gynecomastia

MeSH Terms

Adrenal Gland Neoplasms
Adrenalectomy
Adrenocortical Carcinoma*
Aldosterone
Dehydroepiandrosterone Sulfate
Estradiol
Gynecomastia
Humans
Hydrocortisone
Incidence
Male
Middle Aged
Radiotherapy, Adjuvant
Recurrence
Aldosterone
Dehydroepiandrosterone Sulfate
Estradiol
Hydrocortisone