J Neurogastroenterol Motil.  2015 Jul;21(3):309-319. 10.5056/jnm15105.

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Affiliations
  • 1The Esophageal and Swallowing Center, Division of Gastroenterology and Hepatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA. Ronnie.fass@gmail.com

Abstract

Gastroesophageal reflux disease (GERD) is a highly prevalent gastrointestinal disorder. Proton pump inhibitors have profoundly revolutionized the treatment of GERD. However, several areas of unmet need persist despite marked improvements in the therapeutic management of GERD. These include the advanced grades of erosive esophagitis, nonerosive reflux disease, maintenance treatment of erosive esophagitis, refractory GERD, postprandial heartburn, atypical and extraesophageal manifestations of GERD, Barrett's esophagus, chronic protein pump inhibitor treatment, and post-bariatric surgery GERD. Consequently, any future development of novel therapeutic modalities for GERD (medical, endoscopic, or surgical), would likely focus on the aforementioned areas of unmet need.

Keyword

Gastroesophageal Reflux; Heartburn; Proton Pump Inhibitors

MeSH Terms

Barrett Esophagus
Esophagitis
Gastroesophageal Reflux*
Heartburn
Proton Pump Inhibitors
Proton Pump Inhibitors
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