Nat Prod Sci.
2018 Dec;24(4):293-297. 10.20307/nps.2018.24.4.293.
Effect of Sasa quelpaertensis Nakai Extracts and its Constituent p-coumaric Acid on the Apoptosis of Human Cancer Cell Lines
- Affiliations
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- 1Jeju Sasa Industry Development Agency, Jeju National University, 102 Jejudaehakno, Jeju-si Special Self-Governing Province 63243, Korea. sjkim@jejunu.ac.kr
- 2Department of Biology, Jeju National University, 102 Jejudaehakno, Jeju-si Special Self-Governing Province, 63243, Korea.
- KMID: 2432426
- DOI: http://doi.org/10.20307/nps.2018.24.4.293
Abstract
- Sasa quelpaertensis Nakai leaves contain a mixture of polysaccharides, amino acids, and polyphenols, which mediate various biological activities. For efficient utilization of its leaf, we reported the preparation procedure for phytochemical-rich extract (PRE) using the leaf residue, which was by-product of hot water extraction. This study was undertaken to evaluate the effects of PRE and its major constituent, p-coumaric acid,on the growth of several human cancer cell lines (MKN-74, MKN-45, SNU-1, SNU-16, and HL-60). The ethyl acetate fraction of PRE and p-coumaric acid significantly inhibited the proliferation of MKN-74 and HL-60 cells, respectively, and induced cell apoptosis, down-regulated Bcl-2 and poly (ADP-ribose) polymerase levels, and up-regulated those of Bax and caspase-3. These results show the potential utility of S. quelpaertensis Nakai leaves in cancer prevention.
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