Nat Prod Sci.  2018 Dec;24(4):284-287. 10.20307/nps.2018.24.4.284.

Acronyculatin P, A New Isoprenylated Acetophenone from the Stem Bark of Acronychia pedunculata

• Tanjung M
• Nurmalasari I
• Wilujeng A
• Saputri RD
• Rachmadiarti F
• Tjahjandarie TS

• KMID: 2432424
• DOI: http://doi.org/10.20307/nps.2018.24.4.284

Abstract

A new isoprenylated acetophenone, acronyculatin P (1) as well as two known compounds, 3"²,5"²-diisoprenyl-2"²,4"²-dihydroxy-6"²-methoxyphenylethanone (2) and 3"²-isoprenyl-2"²,4"²,6"²-trihydroxyphenylethanone (3) were isolated from the stem bark of Acronychia pedunculata (L.) Miq. The structures were determined by HRESIMS, 1D and 2D NMR. The inhibitory activity of the isoprenylated acetophenone derivatives against murine leukemia P-388 cells showed compound 1 moderate activity with ICâ‚…â‚€ 15.42 µM.

Keyword

Acronyculatin P; isoprenylated acetophenone; Acronychia pedunculata; P-388 cells

MeSH Terms

Leukemia
Rutaceae*
Thoracica*

Figure

• 

  Fig. 1 Isoprenylated acetophenones 1 – 3 isolated from A. pedunculata.

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  Fig. 2 Selected HMBC correlations for compound 1.

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