Chonnam Med J.  2016 Sep;52(3):212-216. 10.4068/cmj.2016.52.3.212.

Association between Vitamin D Status and Risk of Peripheral Arterial Disease: The Dong-gu Study

• Oh SH
• Kweon SS
• Choi JS
• Rhee JA
• Lee YH
• Nam HS
• Jeong SK
• Park KS
• Ryu SY
• Choi SW
• Shin MH

• KMID: 2432272
• DOI: http://doi.org/10.4068/cmj.2016.52.3.212

Abstract

Low levels of vitamin D have been associated with increased cardiovascular disease risk. However, few studies have evaluated the association between vitamin D status and peripheral arterial disease (PAD). We therefore aimed to investigate whether low 25-hydroxyvitamin D (25(OH)D) levels were associated with increased risk of PAD in the Korean population. This cross-sectional study was conducted among 8,960 subjects aged 50 years or older without known myocardial infarction or stroke. PAD was defined by an ankle brachial blood pressure index <0.9. Multivariate logistic regression was used to evaluate the association between serum 25(OH)D levels and risk of PAD. Of the 8,960 subjects, 3.0% had PAD and the age and sex adjusted prevalence of PAD decreased with the increasing 25(OH)D quartile. After adjusting for potential confounders and parathyroid hormones, serum 25(OH)D levels were associated with a significantly decreased risk of PAD (OR for one SD increase, 0.98; 95% CI, 0.95-1.0, P for trend=0.040). Compared with the first 25(OH)D quartile, the odds of PAD were 0.86 (95% CI, 0.62-1.21), 0.67 (95% CI, 0.46-0.97), and 0.71 (95% CI, 0.49-1.04) for the second, third, and fourth quartiles, respectively. In this cross-sectional study, we found that low serum 25(OH)D levels were associated with an increased risk of PAD, independent of traditional cardiovascular risk factors and parathyroid hormone. Our findings suggest that low vitamin D levels may contribute to PAD in the Korean population.

Keyword

25-Hydroxyvitamin D; Peripheral Arterial Disease; Atherosclerosis

MeSH Terms

Ankle
Atherosclerosis
Blood Pressure
Cardiovascular Diseases
Cross-Sectional Studies
Logistic Models
Myocardial Infarction
Parathyroid Hormone
Peripheral Arterial Disease*
Prevalence
Risk Factors
Stroke
Vitamin D*
Vitamins*
Parathyroid Hormone
Vitamin D
Vitamins

Figure

• 

  FIG. 1 Age and sex adjusted prevalence of peripheral arterial disease according to the quartile of serum 25-hydroxyvitamin D.

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