J Korean Med Assoc.  2019 Jan;62(1):11-17. 10.5124/jkma.2019.62.1.11.

Diagnosis and treatment of latent tuberculosis infection

  • 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. kimjusang@catholic.ac.kr


In order to eliminate tuberculosis worldwide by 2050, effective management of latent tuberculosis infection is essential, and policy-makers have begun to recognize the importance of scaling up preventive therapy. The current guideline recommends targeted latent tuberculosis infection testing that identifies high-risk groups based on risk stratification for progression from latent infection to active disease. Both the tuberculin skin test and interferon-gamma releasing assay have a similar diagnostic efficacy for predicting progression to active tuberculosis. The Korean guideline recommends 9-month isoniazid monotherapy as the standard treatment; however, more evidence supports that short course rifampicin-based regimen is both more effective and tolerable than isoniazid monotherapy.


Latent tuberculosis; Antituberculosis agent; Interferon-gamma release assay; Tuberculin skin test

MeSH Terms

Interferon-gamma Release Tests
Latent Tuberculosis*
Skin Tests

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