Maxillofac Plast Reconstr Surg.
2018 ;40(1):5. 10.1186/s40902-018-0146-4.
Effect of the masseter muscle injection of botulinum toxin A on the mandibular bone growth of developmental rats
- Affiliations
-
- 1Department of Oral and Maxillofacial Surgery, Chungbuk National University Hospital, Cheongju, 28644 South Korea.
- 2Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, 7 Jukhyun-gil, Gangneung, 25457 South Korea. kimsg@gwnu.ac.kr
- 3Department of Orthodontics, College of Dentistry, Gangneung-Wonju National University, Gangneung, 25457 South Korea.
- 4Department of Dentistry, College of Medicine, Hallym University, Chuncheon, 24252 South Korea.
- KMID: 2431928
- DOI: http://doi.org/10.1186/s40902-018-0146-4
Abstract
- BACKGROUND
The objective of this study was to evaluate the influence of masticatory muscle injection of botulinum toxin type A (BTX-A) on the growth of the mandibular bone in vivo.
METHODS
Eleven Sprague-Dawley rats were used, and BTX-A (n = 6) or saline (n = 5) was injected at 13 days of age. All injections were given to the right masseter muscle, and the BTX-A dose was 0.5 units. All of the rats were euthanized at 60 days of age. The skulls of the rats were separated and fixed with 10% formalin for micro-computed tomography (micro-CT) analysis.
RESULTS
The anthropometric analysis found that the ramus heights and bigonial widths of the BTX-A-injected group were significantly smaller than those of the saline-injected group (P < 0.05), and the mandibular plane angle of the BTX-A-injected group was significantly greater than in the saline-injected group (P < 0.001). In the BTX-A-injected group, the ramus heights II and III and the mandibular plane angles I and II showed significant differences between the injected and non-injected sides (P < 0.05). The BTX-A-injected side of the mandible in the masseter group showed significantly lower mandibular bone growth compared with the non-injected side.
CONCLUSION
BTX-A injection into the masseter muscle influences mandibular bone growth.
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