Ann Dermatol.  2019 Feb;31(1):87-90. 10.5021/ad.2019.31.1.87.

Plasmacytoid Dendritic Cells in Pityriasis Rubra Pilaris

Affiliations
  • 1Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon. ossamaabbas2003@yahoo.com

Abstract

No abstract available.


MeSH Terms

Dendritic Cells*
Pityriasis Rubra Pilaris*
Pityriasis*

Figure

  • Fig. 1 (A~C) Psoriasis. (A) Representative case showing classical microscopic features of psoriasis (H&E, ×40). (B) Blood-derived dendritic cell antigen-2 (BDCA-2) immunostaining highlighted plasmacytoid dendritic cells (pDCs) in a superficial perivascular distribution (×100). (C) Patchy myxovirus protein A (MxA) immunostaining of both the epithelium and inflammatory cells (×100). (D~F) PRP. (D) Representative case showing alternating ortho- and parakeratosis, follicular plugging, psoriasiform acanthosis and underlying dermal inflammatory infiltrate (H&E, ×40). (E) BDCA-2 immunostaining highlighted pDCs in a superficial perivascular distribution (×200). (F) Patchy MxA immunostaining of both the epithelium and inflammatory cells (×100).


Reference

1. Saadeh D, Kurban M, Abbas O. Update on the role of plasmacytoid dendritic cells in inflammatory/autoimmune skin diseases. Exp Dermatol. 2016; 25:415–421. PMID: 26837058.
Article
2. Marrouche N, Kurban M, Kibbi AG, Abbas O. Pityriasis rubra pilaris: clinicopathological study of 32 cases from Lebanon. Int J Dermatol. 2014; 53:434–439. PMID: 24783259.
Article
3. Takeichi T, Sugiura K, Nomura T, Sakamoto T, Ogawa Y, Oiso N, et al. Pityriasis rubra pilaris type V as an autoinflammatory disease by CARD14 mutations. JAMA Dermatol. 2017; 153:66–70. PMID: 27760266.
Article
4. Wang T, Liu J, Liu Y, Zheng H. Pityriasis rubra pilaris (PRP) with preceding Epstein-Barr virus infection: a new type PRP with non-HIV virus infection? Chin Med J (Engl). 2014; 127:391. PMID: 24438637.
5. Cecchi R, Giomi A, Tuci F, Bartoli L, Seghieri G. Pityriasis rubra pilaris, Lichen planus, Alopecia universalis and vitiligo in a patient with chronic viral hepatitis C. Dermatology. 1994; 188:239–240. PMID: 8186518.
Article
6. Lerner MR, Braverman IM. Psoriasis, lupus erythematosus, and Pityriasis rubra pilaris: occurrence in one family. Arch dermatol. 1962; 85:229–231. PMID: 14464250.
7. Atanaskova Mesinkovska N, Dawes D, Sood A, Bergfeld W. Acantholytic Pityriasis rubra pilaris associated with imiquimod 3.75% application. Case Rep Dermatol Med. 2011; 2011:412684. PMID: 23198175.
8. Feldmeyer L, Mylonas A, Demaria O, Mennella A, Yawalkar N, Laffitte E, et al. Interleukin 23-helper T cell 17 axis as a treatment target for Pityriasis rubra pilaris. JAMA Dermatol. 2017; 153:304–308.
Article
9. Lande R, Chamilos G, Ganguly D, Demaria O, Frasca L, Durr S, et al. Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self-DNA. Eur J Immunol. 2015; 45:203–213. PMID: 25332209.
Article
10. Garzorz-Stark N, Lauffer F, Krause L, Thomas J, Atenhan A, Franz R, et al. Toll-like receptor 7/8 agonists stimulate plasmacytoid dendritic cells to initiate a TH17-deviated acute contact dermatitis in human subjects. J Allergy Clin Immunol. 2018; 141:1320–1333.e11. PMID: 28935206.
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