Clin Endosc.  2018 Nov;51(6):576-583. 10.5946/ce.2018.053.

Prospective Assessment of the Performance of a New Fine Needle Biopsy Device for EUS-Guided Sampling of Solid Lesions

Affiliations
  • 1Division of Gastroenterology, Section of Interventional Endoscopy, Indiana University School of Medicine, Indianapolis, IN, USA. moalhadd@iu.edu
  • 2Department of Laboratory Medicine and Cytopathology, Indiana University School of Medicine, Indianapolis, IN, USA.

Abstract

BACKGROUND/AIMS
Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) remains the most common EUS-guided tissue acquisition technique. This study aimed to evaluate the performance of a new Franseen tip fine needle biopsy (FNB) device for EUSguided sampling of solid lesions and compare it with the historical FNA technique.
METHODS
Acquire® 22 G FNB needle (Boston Scientific Co., Natick, MA, USA) was used for solid tumor sampling (Study group). Tissue was collected for rapid on-site evaluation, and touch and crush preparations were made. Historical EUS-FNA samples obtained using Expect® 22 G FNA needle (Boston Scientific Co.) were used as controls (Control group). All specimens were independently evaluated by two cytopathologists blinded to the formal cytopathological diagnosis.
RESULTS
Mean cell block histology scores were significantly higher (p=0.046) in the FNB group (51 samples) despite a significantly lower (p < 0.001) mean number of passes compared to the FNA group (50 specimens). The overall diagnostic yields for the FNB vs. FNA groups were 96% vs. 88%. The degree of tumor differentiation was adequately assessed in all cell block qualifying lesions in the FNB group. Two patients developed post-FNB abdominal pain.
CONCLUSIONS
The new Franseen tip FNB device provides histologically superior and cytologically comparable specimens to those obtained by FNA, but with fewer passes.

Keyword

Tissue acquisition; Endoscopic ultrasound-guided fine needle aspiration; Endoscopic ultrasound-guided fine needle biopsy
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