Korean J Gastroenterol.  2018 Dec;72(6):286-294. 10.4166/kjg.2018.72.6.286.

Female Gender is a Poor Predictive Factor of Functional Dyspepsia Resolution after Helicobacter pylori Eradication: A Prospective, Multi-center Korean Trial

• Kim SE
• Kim N
• Park SM
• Kim WH
• Baik GH
• Jo Y
• Park KS
• Lee JY
• Shim KN
• Kim GH
• Lee BE
• Hong SJ
• Park SY
• Choi SC
• Oh JH
• Kim HJ

• KMID: 2429945
• DOI: http://doi.org/10.4166/kjg.2018.72.6.286

Abstract

BACKGROUND/AIMS
The predictive factors of functional dyspepsia (FD) remain controversial. Therefore, we sought to investigate symptom responses in FD patients after Helicobacter pylori (H. pylori) eradication and used predictive factor analysis to identify significant factors of FD resolution at one-year after commencing eradication therapy.
METHODS
This prospective, multi-center clinical trial was performed on 65 FD patients that met Rome III criteria and had H. pylori infection. Symptom responses and factors that predicted poor response were determined by analysis one year after commencing H. pylori eradication therapy.
RESULTS
A total of 63 patients completed the one-year follow-up. When an eradication success group (n=60) and an eradication failure group (n=3) were compared with respect to FD response rate at one year, results were as follows; complete response 73.3% and 0.0%, satisfactory response 1.7% and 0.0%, partial response 10.0% and 33.3%, and refractory response 15.0% and 66.7%, respectively (p=0.013). Univariate analysis showed persistent H. pylori infection (p=0.021), female gender (p=0.025), and medication for FD during the study period (p=0.013) were associated with poor FD response at one year. However, age, smoking, alcohol consumption, and underlying disease were not found to affect response. Finally, multivariate analysis showed that female gender (OR, 4.70; 95% CI, 1.17-18.88) was the sole independent risk factor of poor FD response at one year after commencing H. pylori eradication therapy.
CONCLUSIONS
Female gender was found to predict poor response in FD patients despite H. pylori eradication. Furthermore, successful H. pylori eradication appears to be associated with FD improvement, but the number of non-eradicated patients was too small to conclude.

Keyword

Helicobacter pylori; Dyspepsia; Female; Symptom assessment

MeSH Terms

Alcohol Drinking
Dyspepsia*
Female*
Follow-Up Studies
Helicobacter pylori*
Helicobacter*
Humans
Multivariate Analysis
Prospective Studies*
Risk Factors
Smoke
Smoking
Symptom Assessment
Smoke

Figure

• 

  Fig. 1 Flowchart of participants. H. pylori, Helicobacter pylori.

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