Korean J Radiol.  2019 Jan;20(1):69-82. 10.3348/kjr.2018.0231.

Introduction of a New Staging System of Breast Cancer for Radiologists: An Emphasis on the Prognostic Stage

Affiliations
  • 1Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea. mines@yuhs.ac
  • 2Department of Radiology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Abstract

In 2017, the American Joint Committee on Cancer announced the 8th edition of its cancer staging system. For breast cancer, the most significant change in the staging system is the incorporation of biomarkers into the anatomic staging to create prognostic stages. Different prognostic stages are assigned to tumors with the same anatomic stages according to the tumor grade, hormone receptor (estrogen receptor; progesterone receptor) status, and HER2 status. A Clinical Prognostic Stage is assigned to all patients regardless of the type of therapy used; in contrast, a Pathologic Prognosis Stage is assigned to patients in whom surgery is the initial treatment. In a few situations, low Oncotype DX recurrence scores can change the prognostic stage. The radiologists need to understand the importance of the biologic factors that can influence cancer staging.

Keyword

Breast neoplasm; TNM stage; Biomarker; AJCC; Prognostic stage

MeSH Terms

Biological Factors
Biomarkers
Breast Neoplasms*
Breast*
Humans
Joints
Neoplasm Staging
Progesterone
Prognosis
Recurrence
Biological Factors
Biomarkers
Progesterone
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