Blood Res.  2018 Dec;53(4):329-332. 10.5045/br.2018.53.4.329.

Epstein-Barr virus-positive mucocutaneous ulcer colliding with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (malt lymphoma) that developed in the palatine tonsils of an immunocompetent patient after gastric lymphoma relapse

Affiliations
  • 1Department of Pathology, Dankook University School of Medicine, Cheonan, Korea.
  • 2Department of Pathology, Chungnam National University School of Medicine, Daejeon, Korea. jinmank@cnu.ac.kr

Abstract

No abstract available.


MeSH Terms

Humans
Lymphoma*
Lymphoma, B-Cell, Marginal Zone*
Palatine Tonsil*
Recurrence*
Ulcer*

Figure

  • Fig. 1 Microscopic and immunohistochemical study findings of the patient's gastric MALT lymphoma in the past 2 years. (A) Gastric glands infiltrated by small monotonous lymphocytic cells (H&E, ×200). (B, C) Notable lymphoepithelial lesions demonstrated by the immunohistochemical stain for cytokeratin. (D) Neoplastic B-cells' low proliferative nature demonstrated by the Ki-67 labeling index. Gross and microscopic findings of the palatine tonsils. (E) Enlarged bilateral palatine tonsils covered with purulent exudate and showing shallow ulcer. (F) Low-magnification image showing diffusely effaced follicles with shallow ulcer along the surface epithelium. (G) Small- to medium-sized monotonous neoplastic cells in the nodular area showing irregular nuclei, dispersed chromatin, and inconspicuous nucleoli (H&E, ×400). (H) Low Ki-67 labeling index of neoplastic cells composing the nodular area supporting MALT lymphoma. (I) Ulcer base consisting of solid sheets of large, atypical immunoblast-like cells with many apoptotic bodies (H&E, ×100). (J) Immunoblast-like cells showing irregular nuclear contour, open chromatin, and prominent nucleoli (H&E, ×400). Immunohistochemical staining results of the large cell area. (K) Diffuse CD20-positive solid sheets of immunoblast-like cells in the ulcer base. (L) Bcl-6 positive. (M) MUM-1/IRF-4 positive. (N) High Ki-67 labeling index. (O) Striking demonstration of CD30 reactivity. (P) EBER-ISH reactivity.


Reference

1. Swerdlow SH, Campo E, Harris NL, editors. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. Lyon, France: IARC Press;2017. p. 307–308.
2. Swerdlow SH, Campo E, Harris NL, editors. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. Lyon, France: IARC Press;2017. p. 259–262.
3. Merino F, Martinez CV, Zubillaga I, Aniceto GS, Ballestin C. MALT lymphoma occurring in the maxillofacial region: a review of the literature and case report. Oral Maxillofac Surg Case. 2017; 3:70–75.
Article
4. Dojcinov SD, Venkataraman G, Raffeld M, Pittaluga S, Jaffe ES. EBV positive mucocutaneous ulcer-a study of 26 cases associated with various sources of immunosuppression. Am J Surg Pathol. 2010; 34:405–417. PMID: 20154586.
Article
5. Fujita H, Nishikori M, Takaori-Kondo A, et al. A case of HIV-associated lymphoproliferative disease that was successfully treated with highly active antiretroviral therapy. Int J Hematol. 2010; 91:692–698. PMID: 20217283.
Article
6. Mahe E, Ross C, Sur M. Lymphoproliferative lesions in the setting of HIV infection: a five-year retrospective case series and review. Patholog Res Int. 2011; 2011:618760. PMID: 21559204.
Article
7. Isaacson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer. 1983; 52:1410–1416. PMID: 6193858.
Article
8. Thieblemont C, Bastion Y, Berger F, et al. Mucosa-associated lymphoid tissue gastrointestinal and nongastrointestinal lymphoma behavior: analysis of 108 patients. J Clin Oncol. 1997; 15:1624–1630. PMID: 9193362.
Article
9. Tanaka T, Kitabatake K, Iino M, Goto K. Immunohistochemical comparison of CD5, lambda, and kappa expression in primary and recurrent buccal mucosa-associated lymphoid tissue (MALT) lymphomas. Diagn Pathol. 2011; 6:82. PMID: 21892966.
Article
10. Zullo A, Hassan C, Cristofari F, et al. Effects of Helicobacter pylori eradication on early stage gastric mucosa-associated lymphoid tissue lymphoma. Clin Gastroenterol Hepatol. 2010; 8:105–110. PMID: 19631287.
Article
11. Lee JT, Paquette R, Sercarz JA, Wang MB. Mucosa-associated lymphoid tissue lymphoma of the lingual tonsil. Am J Otolaryngol. 2000; 21:271–276. PMID: 10937914.
Article
12. Paulsen J, Lennert K. Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue type in Waldeyer's ring. Histopathology. 1994; 24:1–11. PMID: 8144136.
Article
13. Thieblemont C, Berger F, Dumontet C, et al. Mucosa-associated lymphoid tissue lymphoma is a disseminated disease in one third of 158 patients analyzed. Blood. 2000; 95:802–806. PMID: 10648389.
Article
14. Raderer M, Vorbeck F, Formanek M, et al. Importance of extensive staging in patients with mucosa-associated lymphoid tissue (MALT)-type lymphoma. Br J Cancer. 2000; 83:454–457. PMID: 10945490.
Article
15. Stephen MR, Farquharson MA, Sharp RA, Jackson R. Sequential malt lymphomas of the stomach, small intestine, and gall bladder. J Clin Pathol. 1998; 51:77–79. PMID: 9577379.
Article
16. Zucca E, Roggero E. Biology and treatment of MALT lymphoma: the state-of-the-art in 1996. A workshop at the 6th International Conference on Malignant Lymphoma. Mucosa-Associated Lymphoid Tissue. Ann Oncol. 1996; 7:787–792. PMID: 8922191.
17. Harris NL. Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue and monocytoid B-cell lymphoma. Related entities that are distinct from other low-grade B-cell lymphomas. Arch Pathol Lab Med. 1993; 117:771–775. PMID: 8343039.
18. Isaacson PG, Spencer J. The biology of low grade MALT lymphoma. J Clin Pathol. 1995; 48:395–397. PMID: 7629280.
Article
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