Yonsei Med J.  2018 Sep;59(7):887-896. 10.3349/ymj.2018.59.7.887.

Diagnostic Ability of Swept-Source and Spectral-Domain Optical Coherence Tomography for Glaucoma

• Lee SY
• Bae HW
• Seong GJ
• Kim CY

• KMID: 2428916
• DOI: http://doi.org/10.3349/ymj.2018.59.7.887

Abstract

PURPOSE
To compare the diagnostic abilities of swept-source optical coherence tomography (OCT) [Deep Range Imaging OCT-1 (DRI-OCT)] and spectral-domain OCT (Cirrus HD-OCT) for glaucoma in Korean adults.
MATERIALS AND METHODS
This retrospective study involved measuring peripapillary retinal nerve fiber layer (PP-RNFL) thickness, full macular thickness, and ganglion cell-inner plexiform layer (GC-IPL) thickness on two different OCT systems. We used three-dimensional optic disc scanning of DRI-OCT and included 12 clock-hour sectors for measurement of the PP-RNFL. Areas under receiver operating characteristic curves (AUCs) were calculated and compared to determine how well each system could distinguish control and glaucomatous patients.
RESULTS
Ninety-one healthy and 58 glaucomatous eyes were included. Both systems could clearly distinguish between control eyes and eyes with moderate to severe glaucoma. Among all sectors, the AUC values of areas associated with glaucoma were >0.7 for both OCTs. The PP-RNFL sector of highest AUC value on both OCTs was the inferior sector of the clock-hour map (0.968 and 0.959 in DRI-OCT and Cirrus HD-OCT, respectively). Among macular thickness sectors, AUC values were highest on both OCTs for the outer inferior sector (0.859 and 0.853 in DRI-OCT and Cirrus HD-OCT, respectively). The GC-IPL also provided high diagnostic values (DRI-OCT and Cirrus HD-OCT were the best in the average and inferior sectors, respectively).
CONCLUSION
Although the two OCT systems provided different thickness measurements, DRI-OCT exhibited as good, if not better, diagnostic ability for glaucoma as Cirrus HD-OCT in Korean adults.

Keyword

Glaucoma; diagnostic ability; spectral domain optical coherence tomography; swept source optical coherence tomography

MeSH Terms

Adult
Area Under Curve
Ganglion Cysts
Glaucoma*
Humans
Nerve Fibers
Retinaldehyde
Retrospective Studies
ROC Curve
Tomography, Optical Coherence*
Retinaldehyde

Figure

• 

  Fig. 1 Sectors used for optical coherence tomography (OCT) thickness measurements of peripapillary retinal nerve fiber layer thickness in both OCT systems (A: 4 sectors, B: 12 sectors). Sectors used for macular thickness (C) and ganglion cell inner plexiform layer thickness (D) measurements are also shown. All sectors shown are those used for right eye analyses. S, superior; N, nasal; I, inferior; T, temporal; SN, superonasal; NS, nasosuperior; NI, nasoinferior; IN, inferonasal; IT, inferotemporal; TI, temporoinferior; TS, temporosuperior; ST, superotemporal; Out S, outer superior; Out N, outer nasal; Out I, outer inferior; Out T, outer temporal; In S, inner superior; In N, inner nasal; In I, inner inferior; In T, inner temporal.

• 

  Fig. 2 Receiver operating characteristics curve of average peripapillary retinal nerve fiber layer thickness (A), macular thickness (B), and ganglion cell-inner plexiform layer thickness (C) measurements made with two optical coherence tomography (OCT) modalities (DRI-OCT and Cirrus HD-OCT) between control and early glaucoma.

• 

  Fig. 3 Receiver operating characteristics curve of average peripapillary retinal nerve fiber layer thickness (A), macular thickness (B), and ganglion cell-inner plexiform layer thickness (C) measurements made with two optical coherence tomography (OCT) modalities (DRI-OCT and Cirrus HD-OCT) between control and moderate to severe glaucoma.

• 

  Fig. 4 Receiver operating characteristics curve of average peripapillary retinal nerve fiber layer thickness (A), macular thickness (B), and ganglion cell-inner plexiform layer thickness (C) measurements made with two optical coherence tomography (OCT) modalities (DRI-OCT and Cirrus HD-OCT) between early and moderate to severe glaucoma.

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