J Korean Ophthalmol Soc.  2018 Dec;59(12):1152-1159. 10.3341/jkos.2018.59.12.1152.

Long-term Results of Taking Anti-oxidant Nutritional Supplement in Intermediate Age-related Macular Degeneration

Affiliations
  • 1Department of Ophthalmology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea. syyu@khu.ac.kr
  • 2Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea.
  • 3Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu, Korea.
  • 4Department of Ophthalmology, Pusan National University School of Medicine, Yangsan, Korea.
  • 5Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
  • 6Blue Eye Center, Seoul, Korea.

Abstract

PURPOSE
We prospectively investigated clinical changes and long-term outcomes after administration of the drugs recommended by the Age-Related Eye Disease Study-2 to patients with intermediate age-related macular degeneration (AMD).
METHODS
This prospective multicenter study enrolled 79 eyes of 55 patients taking lutein and zeaxanthin. The primary endpoint was contrast sensitivity; this was checked every 12 months for a total of 36 months after treatment commenced. The secondary endpoints were visual acuity, central macular thickness, and drusen volume; the latter two parameters were assessed using spectral domain optical coherence tomography.
RESULTS
The mean patient age was 72.46 ± 7.16 years. Contrast sensitivity gradually improved at both three and six cycles per degree. The corrected visual acuity was 0.13 ± 0.14 logMAR and did not change significantly over the 36 months. Neither the central macular thickness nor drusen volume changed significantly.
CONCLUSIONS
Contrast sensitivity markedly improved after treatment, improving vision and patient satisfaction. Visual acuity, central retinal thickness, and drusen volume did not deteriorate. Therefore, progression of AMD and visual function deterioration were halted.

Keyword

Age-Related Eye Disease Study (AREDS)-2 formula; Contrast sensitivity; Drusen volume; Intermediate age-related macular degeneration (AMD)

MeSH Terms

Contrast Sensitivity
Eye Diseases
Humans
Lutein
Macular Degeneration*
Patient Satisfaction
Prospective Studies
Retinaldehyde
Tomography, Optical Coherence
Visual Acuity
Zeaxanthins
Lutein
Retinaldehyde
Zeaxanthins
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