J Bone Metab.  2018 Nov;25(4):213-217. 10.11005/jbm.2018.25.4.213.

Osteoporosis and Osteoporotic Fractures in Gastrointestinal Disease

• Oh HJ
• Ryu KH
• Park BJ
• Yoon BH

• KMID: 2427986
• DOI: http://doi.org/10.11005/jbm.2018.25.4.213

Abstract

Patients with gastrointestinal disease (GI) are at risk for osteopenia or osteoporosis, which can lead to fractures. Although these patients may be at risk from a young age, gastroenterologists often overlook this fact in practice. There are well-known GI diseases associated with osteopenia and osteoporosis, such as the post-gastrectomy state, inflammatory bowel disease (IBD), and celiac disease. As there is an increase in the prevalence of IBD patients, newly diagnosed celiac disease in adulthood, and gastric cancer survivors following gastrectomy, bone disease in these patients becomes an important issue. Here, we have discussed osteoporosis and fractures in GI disease, especially in the post-gastrectomy state, IBD, and celiac disease. Although the pathogenesis of bone loss in each disease has not been fully identified, we have confirmed that the prevalence of osteoporosis and fractures in each of these diseases is high. There are scarce studies comparing the prevalence of osteoporosis or osteoporotic fractures in GI disease patients with studies in postmenopausal women, and specific guidelines for their management in each disease have not been established. Intensive surveillance and management are needed to ensure that these patients attain peak bone mass for age and sex to prevent fractures.

Keyword

Celiac disease; Gastrectomy; Inflammatory bowel diseases; Osteoporosis; Osteoporotic fractures

MeSH Terms

Bone Diseases
Bone Diseases, Metabolic
Celiac Disease
Female
Gastrectomy
Gastrointestinal Diseases*
Humans
Inflammatory Bowel Diseases
Osteoporosis*
Osteoporotic Fractures*
Prevalence
Stomach Neoplasms
Survivors