Korean J Orthod.  2018 Nov;48(6):395-404. 10.4041/kjod.2018.48.6.395.

Association between genetic polymorphisms and external apical root resorption: A systematic review and meta-analysis

• Nowrin SA
• Jaafar S
• Ab Rahman
• Basri R
• Alam MK
• Shahid F

• KMID: 2427777
• DOI: http://doi.org/10.4041/kjod.2018.48.6.395

Abstract

OBJECTIVE
To date, only a few studies have investigated the relationships between genetic polymorphisms and external apical root resorption (EARR). Hence, the aim of this systematic review was to explore the relationship between different gene polymorphisms and their association with EARR.
METHODS
A complete literature search was conducted by two independent reviewers. The PubMed, Science Direct, and Scopus databases were searched. In addition, the bibliographies of all textbooks and relevant articles were searched manually. A meta-analysis was performed using data entered into the electronic databases until February 28, 2017.
RESULTS
On the basis of the search, we identified 17 and 7 publications for the systematic review and meta-analysis, respectively. Odds ratio (OR) was used to evaluate the association of the interleukin 1B (+3954) polymorphism and the risk of EARR. The overall OR from the studies was used to estimate the risk of EARR. However, no association was found and no publication bias was apparent for the risk of EARR in patients receiving orthodontic treatment.
CONCLUSIONS
More research on the relationship between gene polymorphism and EARR is necessary to determine better specificity of possible interactions.

Keyword

Genetics; Root resorption; Tooth movement; Evidence-based orthodontics

MeSH Terms

Genetics
Humans
Interleukins
Odds Ratio
Polymorphism, Genetic*
Publication Bias
Root Resorption*
Sensitivity and Specificity
Tooth Movement
Interleukins

Figure

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  Figure 1 Flow chart of the PRISMA guidelines for study selection.

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  Figure 2 Forest plots of external apical root resorption risk associated with the interleukin-1B polymorphism (CC vs. TT). OR, Odds ratio; 95% CI, 95% confidence interval.

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  Figure 3 Forest plots of external apical root resorption risk associated with the interleukin-1B polymorphism (CT vs. TT). OR, Odds ratio; 95% CI, 95% confidence interval.

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  Figure 4 Forest plots of external apical root resorption risk associated with the interleukin-1B polymorphism (CC+CT vs. TT). OR, Odds ratio; 95% CI, 95% confidence interval.

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  Figure 5 Forest plots of external apical root resorption risk associated with the interleukin-1B polymorphism (CC vs. CT+TT). OR, Odds ratio; 95% CI, 95% confidence interval.

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  Figure 6 Funnel plot for the publication bias test (CT vs. TT).

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