Psychiatry Investig.  2018 Nov;15(11):1079-1086. 10.30773/pi.2018.08.31.

The Relationship between Plasma Oxytocin Levels and Social Anxiety Symptoms

Affiliations
  • 1Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. healthysewon@daum.net
  • 2Workplace Mental Health Institute, Kangbuk Samsung Hospital, Seoul, Republic of Korea.
  • 3Yonsei Forest Mental Health Clinic, Seoul, Republic of Korea.
  • 4Department of Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Abstract


OBJECTIVE
The pathophysiology of social anxiety disorder (SAD) is not yet well understood, but previous research has suggested that oxytocin is associated with social behavior and may play a role in human anxiety states and anxiety-related traits. The aim of this study was to investigate the possible relationship between social anxiety symptoms and plasma oxytocin levels.
METHODS
Twenty-three male patients with SAD and 28 healthy male controls participated in this study. All participants were assessed using the Mini International Neuropsychiatric Interview (MINI) and the Liebowitz Social Anxiety Scale (LSAS). Multivariate regression analysis was performed to identify associations between plasma oxytocin levels and SAD.
RESULTS
In multiple regression models, after controlling for age and years of education, we found that higher oxytocin levels were significantly associated with higher total LSAS scores (R²=0.157, coefficient=0.145, 95% CI=-0.0005-0.291, p=0.051) and fear subscale scores (R²=0.134, coefficient=0.083, 95% CI=0.007-0.159, p=0.034) in the SAD group.
CONCLUSION
In this study, increased plasma oxytocin levels were associated with higher social anxiety symptoms among SAD patients, but not among controls. This might be because among SAD patients, higher oxytocin (OT) secretion is an insufficient compensatory attempt to reduce social anxiety symptoms.

Keyword

Social anxiety disorder; Oxytocin; Liebowitz Social Anxiety Scale; Fear; Avoidance

MeSH Terms

Anxiety Disorders
Anxiety*
Education
Humans
Male
Oxytocin*
Plasma*
Social Behavior
Oxytocin
Full Text Links
  • PI
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr