Endocrinol Metab.  2018 Dec;33(4):447-458. 10.3803/EnM.2018.33.4.447.

Metabolic Syndrome and Insulin Resistance Syndrome among Infertile Women with Polycystic Ovary Syndrome: A Cross-Sectional Study from Central Vietnam

• Le MT
• Nguyen VQ
• Truong QV
• Le DD
• Le VN
• Cao NT

• KMID: 2427440
• DOI: http://doi.org/10.3803/EnM.2018.33.4.447

Abstract

BACKGROUND
Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathies among reproductive-age women. Its metabolic features often overlap with those associated with metabolic syndrome (MS) and insulin resistance syndrome (IRS). The objective of this study was to determine the prevalence and predictors of MS and IRS in infertile Vietnamese women with PCOS.
METHODS
A cross-sectional study was conducted at a tertiary fertility centre at Hue University Hospital from June 2016 to November 2017. A total of 441 infertile women diagnosed with PCOS based on the revised 2003 Rotterdam consensus criteria were enrolled. MS and IRS were defined based on the National Heart, Lung, and Blood Institute/American Heart Association Adult Treatment Panel III 2005 and American College of Endocrinology IRS 2003 criteria, respectively. Complete clinical and biochemical measurements of 318 women were available for analysis. Independent predictors of MS and IRS were identified using multivariate logistic regression.
RESULTS
The overall prevalence of MS and IRS in women with PCOS was 10.4% and 27.0%, respectively. We identified older age (>30 years) and obesity as independent predictors of MS and IRS. Elevated anti-Müllerian hormone levels increased the risk of IRS, but not that of MS.
CONCLUSION
MS and IRS are prevalent disorders among infertile Vietnamese women with PCOS. PCOS is not solely a reproductive problem. Screening and early intervention for MS and/or IRS based on anthropometric, metabolic, and reproductive hormone risk factors should be an integral part of fertility care.

Keyword

Prevalence; Polycystic ovary syndrome; Metabolic syndrome; Insulin resistance; Infertility

MeSH Terms

Adult
Asian Continental Ancestry Group
Consensus
Cross-Sectional Studies*
Early Intervention (Education)
Endocrinology
Female
Fertility
Heart
Humans
Infertility
Insulin Resistance*
Insulin*
Logistic Models
Lung
Mass Screening
Obesity
Polycystic Ovary Syndrome*
Prevalence
Risk Factors
Vietnam*
Insulin

Figure

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  Fig. 1 Receiver operating characteristic curves of body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) for predicting (A) metabolic syndrome and (B) insulin resistance syndrome.

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  Fig. 2 2. Prevalence of metabolic syndrome and insulin resistance syndrome stratified by (A) age, (B) body mass index (BMI), (C) waist circumference (WC), and (D) waist-to-hip ratio (WHR).

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