Korean J Gastroenterol.  2018 Nov;72(5):267-270. 10.4166/kjg.2018.72.5.267.

Malignant Transformation of Inflammatory Hepatocellular Adenoma into Hepatocellular Carcinoma

• Lee YJ
• Joo JW
• Park JY

• KMID: 2426869
• DOI: http://doi.org/10.4166/kjg.2018.72.5.267

Abstract

No abstract available.

MeSH Terms

Adenoma, Liver Cell*
Carcinoma, Hepatocellular*

Figure

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  Fig. 1 Liver dynamic CT showed a hypervascular mass (arrows) with a size of 7.5 cm at the fifth hepatic segment. Contrast enhancement in the arterial phase (A) with wash out in the delayed phase (B) was noted.

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  Fig. 2 Liver magnetic resonance image reveals a capsulated mass (arrows) with a size of 7.5 cm. Pre-contrast (A) and arterial phase (B) T1-weighted images show arterial enhancement of the tumor. Delayed phase (C) depicts washout and capsule enhancement. The lesion shows elevated signal on T2-weighted images (D).

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  Fig. 3 The specimen contained a round-shaped mass with a size of 5.5 cm, which was well-demarcated around the tissue.

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  Fig. 4 Pathologic findings show a well-defined mass (A, H&E, ×40). The liver cell cords are one to two cells thick and the cell density is slightly increased compared to the surrounding liver (B, H&E, ×400). There is increased cellularity in the central part of the tumor along with an increased nucleus-to-cytoplasm ratio and irregular nuclear contours (C, H&E, ×400). HCA, Hepatocellucar adenoma; HCC, Hepatocellular carcinoma.

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  Fig. 5 Immunohistochemistry with glutamine synthetase was cytoplasmic weak positive for HCA (A, glutamine synthetase, ×200) and was cytoplasmic strong positive for HCC (B, glutamine synthetase, ×200). For CRP Immunohistochemisty staining, both HCA and HCC showed positive (C, D, CRP, ×200). Evident sinusoidal capillarization with CD34 staining (E, F, CD34, ×200) and membranous pattern for β-catenin staining (G, H, β-catenin, ×200) was noted for both HCA and HCC. HCA, Hepatocellucar adenoma; HCC, Hepatocellular carcinoma.

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