Int Neurourol J.
2018 Oct;22(Suppl 3):S156-S164. 10.5213/inj.1836224.112.
PI3K-Akt-Wnt Pathway Is Implicated in Exercise-Induced Improvement of Short-term Memory in Cerebral Palsy Rats
- Affiliations
-
- 1Department of Physical Therapy, Kyung Hee University Medical Center, College of Medicine, Kyung Hee University, Seoul, Korea.
- 2Department of Physical Therapy, Hosan University, Gyeongsan, Korea.
- 3Department of Sports Healthcare, College of Humanities & Social Sciences, Inje University, Gimhae, Korea.
- 4Department of Golf Mapping, College of Arts Physical Education, Joongbu University, Geumsan, Korea.
- 5Division of Leisure & Sports Science, Department of Exercise Prescription, Dongseo University, Busan, Korea.
- 6Department of Internal Medicine, Kyung Hee University Hospital at Gandong, College of Medicine, Kyung Hee University, Seoul, Korea.
- 7Department of Anesthesiology and Pain Medicine, Kyung Hee Medical Center, College of Medicine, Kyung Hee University, Seoul, Korea. esthesi@khu.ac.kr
- KMID: 2426694
- DOI: http://doi.org/10.5213/inj.1836224.112
Abstract
- PURPOSE
Maternal lipopolysaccharide (LPS) injection induces neurodevelopmental disorders, such as cerebral palsy. Exercise activates phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt) signaling pathway that enhances neurogenesis. Wnt ligands are also implicated in the hippocampal neurogenesis and synaptic plasticity. Glycogen synthase kinase-3β (GSK-3β) is a downstream molecule of Akt, and GSK-3β is known to modulate hippocampal neurogenesis negatively.
METHODS
Cerebral palsy was made by maternal LPS-injection. On the 5 weeks after birth, treadmill running was applied to the rat pups of the exercise groups, for 30 minutes, 5 times a week during 6 weeks.
RESULTS
Treadmill running alleviated short-term memory impairments of the cerebral palsy rat pups. Hippocampal cell proliferation was increased and hippocampal apoptosis was suppressed by treadmill running in the cerebral palsy rat pups. Hippocampal phosphorylated-PI3K/PI3K ratio, phosphorylated-Akt/Akt ratio, and Wnt expression were enhanced by treadmill running in the cerebral palsy rat pups. In contrast, hippocampal phosphorylated-GSK-3β/GSK-3β ratio and β-catenin expression were suppressed by treadmill running in the cerebral palsy rat pups.
CONCLUSIONS
The results of this study showed that short-term memory improvement due to treadmill running in cerebral palsy occurs via activation of the PI3K-Akt-Wnt pathway.
Keyword
MeSH Terms
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Animals
Apoptosis
Cell Proliferation
Cerebral Palsy*
Glycogen Synthase
Ligands
Memory, Short-Term*
Neurodevelopmental Disorders
Neurogenesis
Neuronal Plasticity
Parturition
Phosphatidylinositol 3-Kinase
Phosphotransferases
Proto-Oncogene Proteins c-akt
Rats*
Running
Glycogen Synthase
Ligands
Phosphatidylinositol 3-Kinase
Phosphotransferases
Proto-Oncogene Proteins c-akt
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