Korean J Med.
2003 Jun;64(6):625-631.
Predictors of successful outcome of acute paraquat poisoning: An analysis of 602 cases
- Affiliations
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- 1Department of Internal Medicine, Soonchunhyang University Medical College, Chonan, Korea. syhong@schch.co.kr
- 2Department of Preventive Medicine, Soonchunhyang University Medical College, Chonan, Korea.
- 3Institute of Pesticide Poisoning, Soonchunhyang University Chonan Hospital, Chonan, Korea.
Abstract
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BACKGROUND: Acute paraquat poisoning has been notorious for fatal outcome. Even though many studies focus on successful treatment modality, there is no standard treatment so far. The purpose of this study was to determine the predictors of successful outcome of acute paraquat poisoning in 602 patients.
METHODS
The paraquat exposure was assessed based on the estimated amount of paraquat and a semi-quantitative measure of urine paraquat. Initial laboratory parameters including hemoglobin, white blood cell count, pH, PaCO2, PaO2, blood urea nitrogen, creatinine, aspartate aminotransferase, alanine aminotransferase, total bilirubin, amylase, lipase, and glucose were obtained at the time of emergency room visit. Outcomes after acute paraquat poisoning were determined as survival and death. Multiple logistic regression analysis was applied to assess the predictors of outcome after acute paraquat poisoning.
RESULTS
The estimated amount of paraquat was 45.6+/-74.1 mL and overall mortality after acute paraquat poisoning was 41.5%, whereas all were survived after skin contact or inhalation of paraquat. In multiple logistic regression analysis, death after acute paraquat poisoning increased significantly with the decreases in pH and PaCO2 and increases in white blood cell count, amylase, lipase, glucose, and paraquat exposure.
CONCLUSION
In conclusion, percutaneous or inhalational route, smaller exposure of paraquat, and lesser degrees of leukocytosis, acidosis, pancreatic failures on admission are good prognostic factors of survival after acute paraquat poisoning.
Keyword
MeSH Terms
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Acidosis
Alanine Transaminase
Amylases
Aspartate Aminotransferases
Bilirubin
Blood Urea Nitrogen
Creatinine
Emergency Service, Hospital
Fatal Outcome
Glucose
Humans
Hydrogen-Ion Concentration
Inhalation
Leukocyte Count
Leukocytosis
Lipase
Logistic Models
Mortality
Paraquat*
Poisoning*
Skin
Alanine Transaminase
Amylases
Aspartate Aminotransferases
Bilirubin
Creatinine
Glucose
Lipase
Paraquat
