Ann Pediatr Endocrinol Metab.  2018 Sep;23(3):136-140. 10.6065/apem.2018.23.3.136.

Evaluation of bone mineral status in prepuberal children with newly diagnosed type 1 diabetes

• Roh JG
• Yoon JS
• Park KJ
• Lim JS
• Lee HS
• Hwang JS

• KMID: 2422477
• DOI: http://doi.org/10.6065/apem.2018.23.3.136

Abstract

PURPOSE
Many studies have reported that patients with type 1 diabetes have reduced bone mineral density (BMD). We assessed bone status in prepubertal children with type 1 diabetes mellitus (type 1 DM) at initial diagnosis and investigated factors associated with BMD.
METHODS
Prepubertal children (n=29) with newly diagnosed type 1 diabetes from 2006 to 2014 were included. Dual-energy X-ray absorptiometry measured regional and whole-body composition at initial diagnosis. BMD was compared with healthy controls matched for age, sex, and body mass index (BMI).
RESULTS
The mean age of all subjects (16 boys and 13 girls) was 7.58±1.36 years (range, 4.8-11.3 years). Initial mean glycosylated hemoglobin (HbA1c) level was 12.2%±1.9%. The mean BMD z-scores of lumbar spine, femur neck, and total body were not significantly different between patients and controls. Three patients (10.3%) had low bone density (total body BMD standard deviation score [SDS] < -2.0). To identify determinants of lumbar spine BMD z-score, multivariate regression analysis was performed with stepwise variable selection of age, pubertal status, BMI SDS, insulin like growth factor-1, and HbA1c. Only BMI SDS was significantly correlated with lumbar spine BMD z-score (β=0.395, P=0.023).
CONCLUSIONS
Prepubertal children with newly diagnosed type 1 DM had similar bone mass compared to healthy peers. However, patients with low BMI should be carefully monitored for bone density in type 1 DM.

Keyword

Bone mineral density; Type 1 diabetes; Body mass index; Child

MeSH Terms

Absorptiometry, Photon
Body Mass Index
Bone Density
Child*
Diabetes Mellitus, Type 1
Diagnosis
Femur Neck
Hemoglobin A, Glycosylated
Humans
Insulin
Miners*
Spine
Insulin

Figure

• 

  Fig. 1. Correlation between bone mineral density (BMD) at lumbar spine and body mass index standard deviation score (BMI SDS) in patients with type 1 diabetes mellitus.

Reference

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